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Etomidate

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Identification
Molecular formula
C14H16N2O2
CAS number
1668-49-9
IUPAC name
1-[1-[2-(diethylamino)ethyl]-2-(4-ethoxyanilino)benzimidazol-5-yl]ethanone
State
State

Etomidate is a solid at room temperature. It is commonly used in its liquid form in medical settings for anesthesia induction.

Melting point (Celsius)
78.60
Melting point (Kelvin)
351.75
Boiling point (Celsius)
504.10
Boiling point (Kelvin)
777.25
General information
Molecular weight
244.34g/mol
Molar mass
244.3390g/mol
Density
1.2300g/cm3
Appearence

Etomidate typically appears as a white crystalline solid. It is often used in its pure form or prepared in an injectable solution for medical use.

Comment on solubility

Solubility of 1-[1-[2-(diethylamino)ethyl]-2-(4-ethoxyanilino)benzimidazol-5-yl]ethanone

The compound 1-[1-[2-(diethylamino)ethyl]-2-(4-ethoxyanilino)benzimidazol-5-yl]ethanone, with its complex structure, presents intriguing characteristics regarding solubility. Here are some key points to consider:

  • Polarity: The presence of both polar (diethylamino and ethoxy) and nonpolar (benzimidazole) functional groups suggests an amphiphilic nature, potentially allowing for solubility in various solvents.
  • Solvent Interactions: This compound may be soluble in polar solvents such as ethanol or methanol due to its polar functional groups, while it could also exhibit reasonable solubility in nonpolar solvents to some extent.
  • Hydrogen Bonding: The possibility of hydrogen bonding interactions increases the affinity of the compound for solvent molecules, enhancing its overall solubility in suitable environments.
  • Temperature Dependence: As is common with many organic compounds, solubility may vary with temperature, typically exhibiting increased solubility at higher temperatures.

In summary, the solubility of this compound is influenced by its unique structural features. When considering its application, always test solubility in different solvents to determine the most effective conditions for use.

Interesting facts

Interesting Facts About 1-[1-[2-(diethylamino)ethyl]-2-(4-ethoxyanilino)benzimidazol-5-yl]ethanone

This compound, a derivative of benzimidazole, is notable for its complex structure and potential applications in various fields, particularly in medicinal chemistry. Here are some intriguing aspects of its characteristics and significance:

  • Pharmacological Potential: Compounds containing the benzimidazole moiety are often studied for their biological activities, including antiviral, antifungal, and anticancer properties. This specific compound may fall under similar investigative research.
  • Structural Diversity: The presence of both a diethylamino and an ethoxyaniline group adds to its structural complexity, potentially influencing its pharmacokinetic and pharmacodynamic profiles.
  • Research Interest: As scientists explore new avenues for drug discovery, variants of benzimidazole are being synthesized to evaluate their effectiveness against various diseases, including cancer.
  • Synergy of Groups: The arrangement of functional groups can lead to synergistic effects, enhancing the biological activity compared to its individual components.
  • Potential in Organic Synthesis: The intricate structure allows chemists to investigate methods for its synthesis, contributing to the broader field of organic chemistry.

Research around compounds like this illustrates the fascinating interplay between structure and function in medicinal chemistry. The ongoing exploration might reveal this compound as a significant player in future pharmaceutical developments.

As always, the complexity of such compounds requires a multidisciplinary approach, combining insights from organic chemistry, pharmacology, and related fields to unlock their full potential.

Synonyms
BRN 0722676
KETONE, 1-(2-(DIETHYLAMINO)ETHYL)-2-p-PHENETIDINO-5-BENZIMIDAZOLYL METHYL
15451-93-1
DTXSID50165653
1-(2-(Diethylamino)ethyl)-2-p-phenetidino-5-benzimidazolyl methyl ketone
5-25-15-00125 (Beilstein Handbook Reference)
DTXCID3088144