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Adapromine hydrochloride

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Identification
Molecular formula
C13H21ClN
CAS number
76144-81-5
IUPAC name
1-(1-adamantyl)-N-methyl-propan-2-amine;hydrochloride
State
State

Adapromine hydrochloride is typically a solid at room temperature.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
332.15
Boiling point (Kelvin)
605.15
General information
Molecular weight
241.77g/mol
Molar mass
241.8270g/mol
Density
1.1000g/cm3
Appearence

Adapromine hydrochloride appears as a white crystalline solid. The crystals are typically small and uniform. It is usually available in powdered form for chemical studies and drug formulations.

Comment on solubility

Solubility of 1-(1-adamantyl)-N-methyl-propan-2-amine;hydrochloride

The solubility of 1-(1-adamantyl)-N-methyl-propan-2-amine;hydrochloride can be understood by considering its ionic nature and structural characteristics. In general, the solubility of a compound in water is influenced by several factors:

  • Ionic vs. Covalent Nature: The compound in question is a hydrochloride salt, indicating that it is an ionic compound, which often enhances solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of functional groups capable of hydrogen bonding can significantly increase solubility. In this case, the amine functional group plays a role in solubility due to its hydrogen bonding capabilities.
  • Size and Structure: The adamantyl group is a polycyclic structure, which may hinder full solubility due to steric effects. However, the overall impact can vary based on the balance between hydrophilicity and hydrophobicity.

Given these factors, one can typically expect 1-(1-adamantyl)-N-methyl-propan-2-amine;hydrochloride to have moderate to high solubility in water, particularly because the hydrochloride form enhances its dissociation into ions. As stated, “salts are generally more soluble than their neutral counterparts.”

In summary, while the bulkiness of the adamantyl moiety might suggest some limitations, the ionic nature and ability to form hydrogen bonds likely contribute to favorable solubility characteristics in aqueous environments.

Interesting facts

Interesting Facts About 1-(1-Adamantyl)-N-methyl-propan-2-amine; Hydrochloride

The compound 1-(1-adamantyl)-N-methyl-propan-2-amine; hydrochloride represents a fascinating intersection of structural chemistry and pharmacology. Often studied for its potential neuropharmacological effects, this compound is a type of substituted amphetamine. Here are some points that highlight its significance:

  • Neurotransmitter Interaction: This compound is believed to act on neurotransmitter systems, particularly affecting the release and reuptake of dopamine and norepinephrine.
  • Adamantane Derivative: The adamantyl group in its structure offers unique steric and electronic properties, which may enhance its biological activity compared to simpler amines.
  • Psychoactive Research: Investigations into this compound have been driven by its potential as a stimulant and its comparison to other known psychoactive substances.
  • Pharmaceutical Applications: Its structure suggests that it may be worth exploring for therapeutic applications in mood disorders, attention deficits, and other neuropsychiatric conditions.

One interesting aspect of its research is the balance between efficacy and safety, as compounds that interact with neurotransmitter systems can lead to diverse outcomes. The study of this compound contributes to our understanding of structure-activity relationships in medicinal chemistry, making it a compelling subject for students and researchers alike.

As chemists continue to unravel the intricacies of such compounds, they remind us that even small molecular modifications can have profound effects on biological activity and therapeutic potential. Thus, 1-(1-adamantyl)-N-methyl-propan-2-amine; hydrochloride serves as a case study in the challenges and opportunities of drug development.

Synonyms
19835-42-8
1-(2-METHYLAMINOPROPYL)ADAMANTANE HYDROCHLORIDE
Adamantylmethamphetamine HCl
1-(1-adamantyl)-N-methylpropan-2-amine;hydrochloride
N-methyl-1-(Adamantan1-yl)-prop-2-ylamine hydrochloride
2-Propylamine, 1-(1-adamantyl)-N-methyl-, hydrochloride
ADAMANTANE, 1-(2-METHYLAMINOPROPYL)-, HYDROCHLORIDE
DTXSID70941673
AKOS015912351
Adamantylmethamphetamine (hydrochloride)
CS-0065898
1-(Adamantan-1-yl)-N-methylpropan-2-amine--hydrogen chloride (1/1)