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Fluphenazine

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Identification
Molecular formula
C22H26F3N3OS
CAS number
69-23-8
IUPAC name
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-2-morpholino-ethanone
State
State

At room temperature, Fluphenazine is in a solid state. It is usually found as a free base or in various salt forms which are used in pharmaceutical applications.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
626.70
Boiling point (Kelvin)
899.90
General information
Molecular weight
437.57g/mol
Molar mass
437.5650g/mol
Density
1.3100g/cm3
Appearence

Fluphenazine typically appears as a white to off-white crystalline powder. It may have a slightly yellowish tinge depending on the form and purity.

Comment on solubility

Solubility of 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-2-morpholino-ethanone (C22H26F3N3OS)

The solubility of 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-2-morpholino-ethanone is a critical aspect to consider for its applications and effectiveness. This compound is classified as a phenothiazine derivative, and its solubility can vary significantly based on the solvent used and environmental conditions.

Factors Influencing Solubility

  • Polarity: The presence of both hydrophobic (phenothiazine moiety) and hydrophilic (morpholino group) features suggests a potential for variable solubility in polar and non-polar solvents.
  • Temperature: Like many organic compounds, an increase in temperature often enhances solubility due to increased molecular movement.
  • pH Levels: The morpholino group can impart basic properties; thus, solution pH can influence its ionization state, impacting solubility.

In general, phenothiazines are known for their moderate to good solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), but may exhibit limited solubility in water. This characteristic is essential in pharmacological contexts, especially for drug formulation and delivery.

Remember: When assessing solubility, it is important to consider the specific formulation and desired concentration for any practical applications.

Interesting facts

Interesting Facts about 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-2-morpholino-ethanone

This intriguing compound, known for its complex structure and multifaceted applications, is a member of the phenothiazine class. Here are some fascinating insights:

  • Pharmaceutical Relevance: Compounds like this one are often investigated in the field of medicinal chemistry due to their potential as therapeutic agents. Specifically, phenothiazines are well-established in the treatment of psychiatric disorders and have been used as antipsychotic medications.
  • Molecular Complexity: The compound features a unique combination of functional groups, including a dimethylamino group and a morpholino moiety. This structural diversity enhances its interactions with biological targets, potentially improving its efficacy.
  • Activity Spectrum: Research suggests that compounds with a phenothiazine backbone exhibit a broad spectrum of biological activities, which can include antidepressant, antihistaminic, and antimicrobial effects. This sophisticated activity profile makes the compound a subject of interest in drug development.
  • Mechanism of Action: Often, phenothiazines work by antagonizing dopamine receptors in the brain, which can help to alleviate symptoms of various mental health disorders. Understanding the mechanism can pave the way for novel therapeutic strategies.
  • Investigation of Toxicity: As with many pharmacologically active compounds, toxicity profiles are an important area of study. Researchers are keen to explore the safety and side effects associated with the use of such compounds in clinical settings.

As a remarkable example of how chemical structure relates to biological function, 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-2-morpholino-ethanone continues to be a focus of ongoing research in both academic and pharmaceutical laboratories.

Synonyms
13082-24-1
BRN 0584312
Phenothiazine, 10-(2-(dimethylamino)propyl)-2-(morpholinoacetyl)-
KETONE, 10-(2-(DIMETHYLAMINO)PROPYL)PHENOTHIAZIN-2-YL MORPHOLINOMETHYL-
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-2-morpholin-4-ylethanone
10-(2-Dimethylaminopropyl)-10H-phenothiazin-2-yl(morpholinomethyl) ketone
DTXSID90926927
1-{10-[2-(DIMETHYLAMINO)PROPYL]-10H-PHENOTHIAZIN-2-YL}-2-(MORPHOLIN-4-YL)ETHAN-1-ONE