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Trimeprazine

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Identification
Molecular formula
C18H22N2OS
CAS number
84-96-8
IUPAC name
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
State
State

Trimeprazine is typically a solid at room temperature. It can be handled as a powder.

Melting point (Celsius)
104.50
Melting point (Kelvin)
377.65
Boiling point (Celsius)
455.20
Boiling point (Kelvin)
728.35
General information
Molecular weight
370.53g/mol
Molar mass
370.5250g/mol
Density
1.1810g/cm3
Appearence

Trimeprazine can appear as a crystalline powder. The color can vary from white to slightly yellow-tinted depending on purity and conditions.

Comment on solubility

Solubility of 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone

The solubility of 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone can be characterized by various factors that impact its behavior in solution. Understanding these factors is crucial for applications in medicinal chemistry and formulations.

  • Polarity: The presence of a dimethylamino group suggests that the compound may exhibit some degree of polarity, which could affect its solubility in polar solvents.
  • Solvent Compatibility: This compound is likely to have varying solubility in different solvents:
    • Polar solvents: It may dissolve better in polar solvents such as water or alcohol.
    • Non-polar solvents: The aromatic components may enhance solubility in non-polar organic solvents such as chloroform or benzene.
  • Structural Factors: The bulky phenothiazine structure might hinder full solubility due to steric effects, thus making the compound less soluble in certain media.

As a general observation, the solubility of pharmaceutical compounds is often critical to their efficacy and absorption. Testing solubility in various media will provide deeper insights into the practical applications of this compound.


Interesting facts

Interesting Facts about 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone

1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone, commonly referred to in the scientific community as a phenothiazine derivative, showcases a fascinating range of properties and applications:

  • Antipsychotic Properties: This compound is structurally related to certain antipsychotic medications, indicating its potential as a psychotropic agent. It highlights the importance of the phenothiazine moiety in medicinal chemistry.
  • Biological Activity: Phenothiazine derivatives are known for their ability to interact with various neurotransmitter receptors, particularly dopamine receptors. This interaction underscores their significance in neuropharmacology.
  • Versatile Synthesis: The synthesis of 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone can involve multiple synthetic pathways, offering flexibility for chemists. This allows for the exploration of different derivatives and their respective biological activities.
  • Research Applications: Beyond their medicinal capabilities, compounds like this one are often used in scientific research to investigate receptor binding and to develop new therapeutic agents. They serve as valuable tools in understanding complex biological processes.
  • Potential Side Effects: While beneficial, it's essential for researchers and medical professionals to be aware of the side effects associated with such compounds, which can include sedation and extrapyramidal symptoms, emphasizing the need for responsible usage.

In summary, 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone is not only significant due to its structural and pharmacological properties but also serves as a reminder of the intricate relationship between chemistry and medicine. As students and researchers delve deeper into its functionalities, they may uncover further therapeutic potentials and gain insights into the complex mechanisms of action in biological systems.

Synonyms
Aceprometazine
Acepromethazine
13461-01-3
Aceprometazina
Aceprometazinum
10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone
CB 1664
984N9YTM4Y
CHEBI:53770
CB-1664
1-(10-(2-(Dimethylamino)propyl)-10H-phenothiazin-2-yl)ethanone
DTXSID00864407
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone
DTXCID00812928
1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)ethan-1-one
236-661-9
Aceprometazinum [INN-Latin]
Aceprometazina [INN-Spanish]
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
1664CB; Acepromethazine
Aceprometazine [INN:DCF]
1664 CB
EINECS 236-661-9
BRN 0038528
UNII-984N9YTM4Y
Ethanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-
KETONE, 10-(2-(DIMETHYLAMINO)PROPYL)PHENOTHIAZIN-2-YL METHYL
ACEPROMETAZINE [INN]
4-27-00-02910 (Beilstein Handbook Reference)
SCHEMBL142393
ACEPROMETAZINE [MART.]
orb1689120
ACEPROMETAZINE [WHO-DD]
CHEMBL2104054
SCHEMBL29497450
SCHEMBL29688253
HY-A0243
DB01615
DA-60713
CS-0017587
NS00001288
Q2823821
1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]ethanone; 10-[2-(Dimethylamino)propyl]phenothiazin-2-yl Methyl Ketone; 1664CB; Aceprometazine