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Fenergan

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Identification
Molecular formula
C17H20N2OS
CAS number
60-87-7
IUPAC name
1-[10-[3-[4-(2-hydroxyethyl)-1-piperidyl]propyl]phenothiazin-2-yl]ethanone
State
State

In its pure form, Promethazine is a solid at room temperature.

Melting point (Celsius)
60.50
Melting point (Kelvin)
333.65
Boiling point (Celsius)
324.80
Boiling point (Kelvin)
597.95
General information
Molecular weight
284.42g/mol
Molar mass
284.3830g/mol
Density
1.1920g/cm3
Appearence

Promethazine, commonly known as Fenergan in the pharmaceutical industry, typically appears as a white to faint yellow crystalline powder. It is known for its propensity to darken upon prolonged air exposure due to oxidation, necessitating its storage in light-resistant containers.

Comment on solubility

Solubility Characteristics of 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidyl]propyl]phenothiazin-2-yl]ethanone

The solubility of 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidyl]propyl]phenothiazin-2-yl]ethanone is influenced by its complex chemical structure, which incorporates various functional groups that can affect its interactions with solvents. Here are some key points regarding its solubility:

  • Polar and Nonpolar Characteristics: The presence of the hydroxyethyl group contributes to the compound's polarity, enhancing solubility in polar solvents such as water.
  • Organic Solvents: It may exhibit reasonable solubility in organic solvents like alcohols and dimethyl sulfoxide (DMSO), owing to its hydrophobic phenothiazine moiety.
  • Temperature Dependence: As with many compounds, solubility may increase with temperature due to enhanced molecular motion and interactions.
  • pH Influence: The solubility can be affected by the pH of the solution, especially if the compound can ionize in acidic or basic conditions.

In summary, while the compound shows appreciable solubility in various solvents, it is essential to consider specific solvent properties and external conditions that might further influence its dissolving behavior. Always refer to empirical data for the most accurate understanding of solubility in practical applications.

Interesting facts

Interesting Facts about 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidyl]propyl]phenothiazin-2-yl]ethanone

1-[10-[3-[4-(2-hydroxyethyl)-1-piperidyl]propyl]phenothiazin-2-yl]ethanone is a fascinating compound that belongs to the class of phenothiazine derivatives. These compounds have garnered significant interest in medicinal chemistry due to their diverse pharmacological profiles. Here are some captivating facts about this compound:

  • Diverse Applications: The phenothiazine structure is known for its applications in antipsychotic medications, which have a long history in treating various mental health disorders.
  • Unique Structure: This compound features a piperidine moiety alongside a hydroxyethyl attach, showcasing its potential for specific interactions with biological targets.
  • Mechanism of Action: Phenothiazines often act by blocking dopamine receptors, which is crucial for their antipsychotic effects. Understanding this mechanism can aid in developing newer therapeutics.
  • Research Potential: The distinct functional groups present in the structure of this compound may allow researchers to explore novel pharmacological effects, leading to new therapeutic avenues.
  • Historical Significance: Compounds like this have played a major role in advancing the field of psychopharmacology since the introduction of the first phenothiazine tranquilizers in the mid-20th century.

In summary, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidyl]propyl]phenothiazin-2-yl]ethanone is more than just a chemical formula; it represents a critical component of ongoing research to enhance the understanding and treatment of mental illnesses. As science progresses, compounds like this inspire innovations that can profoundly impact healthcare.

Synonyms
PIPERACETAZINE
3819-00-9
Quide
Psymod
Piperacetazina
Piperacetazinum
Piperazetazina
PC-1421
Piperacetazina [INN-Spanish]
SC 9794
EINECS 223-312-0
UNII-KL6248WNW4
Piperacetazinum [INN-Latin]
NSC-760067
KL6248WNW4
DTXSID7023481
10-(3-(4-(2-Hydroxyethyl)piperidino)propyl)phenothiazin-2-yl methyl ketone
Ethanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperidinyl)propyl)-10H-phenothiazin-2-yl)-
DTXCID903481
Piperacetazine [USAN:USP:INN]
2-Acetyl-10-(3-(4-(beta-hydroxyethyl)piperidino)propyl)phenothiazine
Ketone, 10-(3-(4-(2-hydroxyethyl)piperidino)propyl)phenothiazin-2-yl methyl
1-(10-(3-(4-(2-Hydroxyethyl)-1-piperidinyl)propyl)-10H-phenothiazin-2-yl)ethanone
NSC 760067
Piperacetazinum (INN-Latin)
Piperacetazina (INN-Spanish)
PIPERACETAZINE (MART.)
PIPERACETAZINE [MART.]
Piperacetazine (USAN:USP:INN)
10-[3-[4-(2-hydroxyethyl)piperidino]propyl]phenothiazin-2-yl methyl ketone
Ethanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-10H-phenothiazin-2-yl]-
1-(10-{3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl}-10H-phenothiazin-2-yl)ethanone
223-312-0
1-[10-[3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl]phenothiazin-2-yl]ethanone
NCGC00016642-01
CAS-3819-00-9
Piperazetazina [DCIT]
Quide (TN)
Prestwick0_001048
Prestwick1_001048
Prestwick2_001048
Prestwick3_001048
PIPERACETAZINE [MI]
CHEMBL1584
Piperacetazine (USAN/INN)
PIPERACETAZINE [INN]
BSPBio_000976
PIPERACETAZINE [USAN]
MLS002154124
PIPERACETAZINE [VANDF]
SCHEMBL148569
SPBio_002908
BPBio1_001074
PIPERACETAZINE [WHO-DD]
CHEBI:92293
HMS1571A18
HMS2098A18
HMS2230G17
HMS3369H17
HMS3715A18
Pharmakon1600-01503874
PIPERACETAZINE [GREEN BOOK]
DAA81900
HY-B1152
PIPERACETAZINE [ORANGE BOOK]
Tox21_110540
NSC760067
AKOS030526141
Tox21_110540_1
CCG-213229
CS-4756
NCGC00016642-02
NCGC00016642-04
NCGC00179353-01
AS-56571
DA-76910
SMR001233431
AB00514021
NS00030354
D02679
D85498
EN300-221562
AB00514021_06
SR-01000841199
Q3905512
SR-01000841199-2
BRD-K16277217-001-10-9
Z2065671295
2-Acetyl-10-(3-(4-(.beta.-hydroxyethyl)piperidino)propyl)phenothiazine
1-(10-(3-[4-(2-Hydroxyethyl)-1-piperidinyl]propyl)-10H-phenothiazin-2-yl)ethanone #
1-(10-{3-[4-(2-hydroxyethyl)piperidin-1-yl]propyl}-10H-phenothiazin-2-yl)ethanone
1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone
1-(10-{3-[4-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PROPYL}-10H-PHENOTHIAZIN-2-YL)ETHAN-1-ONE