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Trifluoperazine

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Identification
Molecular formula
C21H24ClN3OS
CAS number
117-89-5
IUPAC name
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone
State
State

At room temperature, Trifluoperazine is typically found in a solid state.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.15
Boiling point (Celsius)
508.90
Boiling point (Kelvin)
782.05
General information
Molecular weight
407.55g/mol
Molar mass
407.5190g/mol
Density
1.3682g/cm3
Appearence

Trifluoperazine generally appears as a white to creamy white crystalline solid. Depending on the specific formulation and conditions, the appearance might slightly vary but is commonly found in this solid state.

Comment on solubility

Solubility of 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone

The solubility of the compound 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone exhibits intriguing characteristics due to its complex molecular structure. Factors affecting its solubility include:

  • Polarity: The presence of the 2-hydroxyethyl group contributes polar characteristics, potentially enhancing solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl (-OH) group may form hydrogen bonds with solvent molecules, further the solubility in aqueous environments.
  • Aliphatic and Aromatic Structures: The combination of aliphatic chains and aromatic rings in its structure results in mixed solubility characteristics, possibly favoring organic solvents as well.

As a result of these factors, it can be anticipated that the solubility profile would show:

  1. Higher solubility in polar organic solvents.
  2. Moderate solubility in water due to hydrogen bonding.
  3. Low solubility in non-polar solvents.

Understanding the solubility of this compound is essential, as it dictates its bioavailability and functional applications in various fields.

Interesting facts

Interesting Facts about 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone

This compound, known as a phenothiazine derivative, is notable for its applications in the fields of medicine and pharmacology. Here are some engaging points to consider:

  • Phenothiazine Backbone: The phenothiazine scaffold is widely recognized for its therapeutic potential, particularly in the treatment of psychiatric disorders. Its structure allows for interactions with various neurotransmitter systems in the brain.
  • Antipsychotic Properties: Compounds like this one are often explored for their antipsychotic effects. They influence dopamine receptors, which play a significant role in mood and behavior regulation.
  • Piperazine Ring: The inclusion of a piperazine moiety is crucial, as it enhances the solubility and biological activity of the compound. This ring structure is commonly found in many psychoactive drugs.
  • Hydroxyethyl Group: The hydroxyethyl substituent not only may improve the compound's interaction with biological targets but also aids in enhancing water solubility, which is vital for bioavailability.
  • Chemical Versatility: This compound's unique structure allows it to participate in various chemical reactions, making it a valuable candidate for further modification to enhance its activity or reduce side effects.

As a scientist, exploring the mechanisms of such compounds can reveal insights into the treatment of neurological diseases and the development of new pharmacological agents. The interaction between its components holds significant promise for designing tailored therapies that can address complex mental health conditions.

In summary, the fascinating structure and potential applications of 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone showcase the intricate relationship between chemistry and medicine.

Synonyms
ACETOPHENAZINE
2751-68-0
Acetophenazinum
Acephenazinum
Acetophenazine [INN]
Acetophenazina
Acetophenazinum [INN-Latin]
Acetophenazina [INN-Spanish]
Acetofenazina
CHEBI:2401
8620H6K4QH
ACETOPHENAZINE [MI]
10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl ketone
ACETOPHENAZINE [VANDF]
Ketone, 10-(3-(4-(2-hydroxyethyl-1-piperazinyl)propyl)phenothiazin-2-yl methyl
ACETOPHENAZINE [WHO-DD]
DTXSID2022547
1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethanone
Ethanone, 1-(10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-10H-phenothiazin-2-yl)-
1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethan-1-one
Acetophenazinum (INN-Latin)
Acetophenazina (INN-Spanish)
Ethanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-
1-(10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-10H-phenothiazin-2-yl)ethan-1-one
1-(10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-10H-phenothiazin-2-yl)ethanone
DTXCID202547
N05AB07
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone
NCGC00181120-01
UNII-8620H6K4QH
CHEMBL1085
SCHEMBL94266
BDBM82475
WNTYBHLDCKXEOT-UHFFFAOYSA-N
NSC_17676
DB01063
Ketone, 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazin-2-yl methyl
NCGC00181120-02
DA-50131
TS-09225
CAS_5714-00-1
HY-116916
CS-0066801
NS00046140
C06807
EN300-19767181
L000816
Q4673284
BRD-K42938903-332-01-1
1-(10-(3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl)-10H-phenothiazin-2-yl)ethanone #