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Chlorpromazine

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Identification
Molecular formula
C17H19ClN2OS
CAS number
50-53-3
IUPAC name
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one
State
State

At room temperature, chlorpromazine is in a solid state, typically existing as a stable, crystalline powder.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
213.00
Boiling point (Kelvin)
486.15
General information
Molecular weight
355.85g/mol
Molar mass
355.8450g/mol
Density
1.2800g/cm3
Appearence

Chlorpromazine typically appears as a white or slightly creamy, crystalline powder. It is not very soluble in water, but dissolves in methanol, ethanol, and chloroform. It may appear slightly discolored with exposure to light or air.

Comment on solubility

Solubility of 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one

The solubility of 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one can be influenced by several factors due to its complex structure and the presence of various functional groups. Here are some key aspects to consider:

  • Polarity: The compound features a hydroxyl group, which typically increases its polarity, potentially enhancing solubility in polar solvents like water.
  • Hydrogen Bonding: The -OH group can engage in hydrogen bonding, which may further promote solubility in aqueous environments.
  • Solvent Compatibility: Given its structural characteristics, the solubility might be favorable in solvent systems including:
    • Water
    • Alcohols
    • Aromatic hydrocarbons
  • Temperature Effects: Increased temperature often enhances solubility for many organic compounds, so testing at elevated temperatures may yield different results.
  • Concentration Variables: The solubility is also concentration-dependent; it may exhibit different solubility profiles at varying concentrations.

In conclusion, while specific solubility data for this compound can vary, it is likely to be appreciably soluble in polar solvents due to its functional groups. Further experimental analyses would provide more accurate and detailed insights into its solubility characteristics.

Interesting facts

Exploring 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one

This compound, often regarded as a member of the phenothiazine family, presents fascinating characteristics and applications in the realm of medicinal chemistry. Here are some notable insights:

  • Complex Structure: The intricate structure of this compound is a testament to the diverse functionalities it can accommodate. With elements like a piperazine ring and a hydroxyethyl side group, its chemical architecture allows for a range of interactions in biological systems.
  • Pharmacological Potential: Compounds within the phenothiazine category are widely recognized for their therapeutic roles, particularly as antipsychotic agents. Their ability to interact with neurotransmitter systems makes them a focus for research in treating various mental health disorders.
  • Research Applications: The presence of a hydroxyethyl group offers potential for increased solubility and bioavailability, making this compound an interesting study subject for enhancing drug delivery mechanisms.
  • Innovative Chemistry: The synthetic pathways to create such complex molecules undergo rigorous optimization, showcasing the skill and creativity inherent in organic chemistry. These methods often involve multi-step reactions that highlight the importance of reaction conditions and reagents.
  • Versatile Linker: The design employs a propanone moiety as a linker, suggesting that this compound might interact with other biological or chemical systems, paving the way for conjugation with additional active moieties or carriers.

In summary, 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one is more than a mere chemical formula; it embodies a realm of possibilities that chemistry brings to the field of medicine and beyond. As we continue to unravel its potential, this compound serves as a perfect example of the intersection between structure and function in chemical biology.

Synonyms
Carphenazine
Carfenazine
2622-30-2
Carphenazin
Procethazine
Carfenazina
Carfenazine [INN:BAN]
Carfenazinum
Carfenazinum [INN-Latin]
Carfenazina [INN-Spanish]
EINECS 220-072-9
CLY16Y8Z7E
CARFENAZINE [INN]
CARPHENAZINE [MI]
CARFENAZINE [WHO-DD]
1-(10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl)-1-propanone
DTXSID8022745
1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)propan-1-one
Proketazin
Carfenazinum (INN-Latin)
Carfenazina (INN-Spanish)
1-(10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-10H-phenothiazin-2-yl)propan-1-one
1-[10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]phenothiazin-2-yl]-1-propanone
DTXCID802745
220-072-9
1-(10-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethyl)-10h-phenothiazin-2-yl)propan-1-one
1-(10-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}-10h-phenothiazin-2-yl)propan-1-one
chebi:51235
1-Propanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one
Carphenazin; Carphenazine; Proketazine
NCGC00181121-01
UNII-CLY16Y8Z7E
Carfenazine free base
Oprea1_747021
Wy-2445 (Salt/Mix)
SCHEMBL120591
GTPL7140
Carphenazine maleate (Salt/Mix)
CHEMBL1201328
CAA62230
HY-A0211
MFCD00866712
AKOS003589058
DB01038
1-Propanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazin-2-yl]-
TS-10064
DB-226012
CS-0017558
NS00009212
Q5045786
1-(10-(3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl)-10H-phenothiazin-2-yl)-1-propanone #