Skip to main content

Methopromazine

ADVERTISEMENT
Identification
Molecular formula
C20H24N2OS
CAS number
60-99-1
IUPAC name
1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
State
State

At room temperature, methopromazine is a solid. It is stable under normal conditions, but care should be taken to avoid moisture and light, which can degrade the compound over time.

Melting point (Celsius)
108.00
Melting point (Kelvin)
381.20
Boiling point (Celsius)
550.30
Boiling point (Kelvin)
823.50
General information
Molecular weight
372.53g/mol
Molar mass
372.5300g/mol
Density
1.1760g/cm3
Appearence

Methopromazine typically appears as a pale blue or green crystalline solid. It may also be found in powder form depending on its preparation or intended use. This phenothiazine derivative is often processed for its application in medicinal formulations.

Comment on solubility

Solubility of 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone (C20H24N2OS)

The solubility of the compound 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone can be influenced by its unique structural characteristics and functional groups. Here are some important aspects to consider:

  • General Solubility: Given the presence of both an aromatic system and a dimethylamino group, the compound may exhibit moderate solubility in polar solvents like water, as well as in organic solvents such as ethanol and methanol.
  • Polar and Non-Polar Interactions: The dimethylamino group could enhance the solubility in polar solvents through hydrogen bonding and dipole interactions, while the phenothiazine moiety may contribute to solubility in non-polar environments due to its hydrophobic character.
  • pH Dependence: The solubility may vary with pH. At lower pH levels, the protonation of the amino group can increase solubility in aqueous solutions, while at higher pH levels, it may lead to decreased solubility.
  • Temperature Influence: As with many organic compounds, the solubility is likely to increase with temperature due to enhanced molecular motion.

Overall, the solubility of this compound can be described as complex and multifaceted, relying on various interactions that facilitate its dissolution in different environments. Understanding its solubility profile is essential for applications in pharmaceuticals, where bioavailability can significantly influence drug efficacy.

Interesting facts

Interesting Facts About 1-[10-[3-(Dimethylamino)propyl]phenothiazin-2-yl]ethanone

This fascinating compound falls under the category of phenothiazines, a well-known class of molecules predominantly recognized for their pharmacological properties. Here are some noteworthy points about this compound:

  • Pharmaceutical Relevance: Compounds like this one are often investigated for their potential use as antipsychotic agents. Their structure allows them to interact with various neurotransmitter receptors in the brain, providing therapeutic benefits.
  • Structural Complexity: The presence of the dimethylamino group allows this compound to possess distinctive electronic properties, enhancing its reactivity and interaction with biological targets.
  • Diverse Applications: Beyond their medicinal use, molecules like 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone can be explored for other applications, including research in the field of diagnostics and imaging.
  • Synthetic Pathways: The synthesis of such complex compounds requires intricate multistep processes, showcasing the creativity and problem-solving skills necessary in organic chemistry.

Quote from the Field

As Dr. Emil Fischer once said, "Chemistry knows no boundaries, it constantly challenges the intellect and invites innovation." This compound exemplifies how the fusion of different chemical structures can lead to valuable insights in pharmacology and therapeutic development.

Overall, 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone serves as a unique model for studying the intricate relationship between molecular structure and biological function, paving the way for further exploration in medicinal chemistry.

Synonyms
ACEPROMAZINE
Acetylpromazine
Acetopromazine
61-00-7
Acepromazina
Azepromazine
Plegicil
Vetranquil
Atsetozin
Notensil
Plivafen
Promazine, acetyl-
Anergan
Atravet
Acezine 2
Acepromazin
Acepromazinum
Acetacin
Acetazin
10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone
Concentrat vo34
10-(3-Dimethylaminopropyl)phenothiazine-3-ethylone
SV-1522
WY-1172
2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine
1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
AY-57,062
2-Acetylpromazine
Acepromazinum [INN-Latin]
Acepromazina [INN-Spanish]
EINECS 200-496-0
Ethanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-
UNII-54EJ303F0R
1522 CB
CHEBI:44932
54EJ303F0R
1-(10-(3-(Dimethylamino)propyl)-10H-phenothiazin-2-yl)ethanone
Ethanone, 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
1-[10-(3-DIMETHYLAMINO-PROPYL)-10H-PHENOTHIAZIN-2-YL]-ETHANONE
61-00-7 (free base)
CHEMBL39560
1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone
EC 200-496-0
1522CB
Acepromazine (INN)
Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl methyl
ACEPROMAZINE [INN]
Acepromazinum (INN-Latin)
Acepromazina (INN-Spanish)
3-Acetyl-10-(3-dimethylaminopropyl)phenothiazine
ACEPROMAZINE (MART.)
ACEPROMAZINE [MART.]
10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone
10-(3-(DIMETHYLAMINO)PROPYL)PHENOTHIAZIN-2-YL METHYL KETONE
Acepromazine [INN:BAN]
NSC264522
NCGC00016634-01
PMZ
CAS-3598-37-6
Acepromizina
Acetilpromazina
Acetylperazine
Acetylpromazin
Azapromazine
Vetranquill
Plivaphen
Ketone, 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl
acetyl-promazine
A 23051
1-(10-(3-DIMETHYLAMINO-PROPYL)-10H-PHENOTHIAZIN-2-YL)-ETHANONE
3-Acetyl-promazin
Anatran (Salt/Mix)
Sedalin (Salt/Mix)
Plegicyl (Salt/Mix)
Soprintin (Salt/Mix)
Soprontin (Salt/Mix)
Concentrat vo34 (TN)
Prestwick0_000576
Prestwick1_000576
Prestwick2_000576
Prestwick3_000576
ACEPROMAZINE [MI]
SCHEMBL73018
BSPBio_000392
ACEPROMAZINE [WHO-DD]
SPBio_002611
BPBio1_000432
CC64
DTXSID1022552
N05AA04
BDBM50131719
DB01614
NCGC00016634-02
NCGC00016634-05
NCGC00016634-09
SBI-0206796.P001
1522 C. B.
NS00008480
D07065
Q425097
10-(3-Dimethylaminopropyl)phenothiazine-3-ethanone
2-Acetyl-10-[3-(Dimethylamino)propyl]phenylthiazine
BRD-K37814297-050-05-4
BRD-K37814297-050-09-6
1-(10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl)ethanone #
1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-ethanone
10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl methyl ketone
1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one
200-496-0