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Promazine

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Identification
Molecular formula
C17H20N2OS
CAS number
58-40-2
IUPAC name
1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
State
State

At room temperature, promazine is a solid.

Melting point (Celsius)
88.00
Melting point (Kelvin)
361.15
Boiling point (Celsius)
325.00
Boiling point (Kelvin)
598.15
General information
Molecular weight
284.42g/mol
Molar mass
284.4090g/mol
Density
1.0870g/cm3
Appearence

Promazine is a yellow to orange crystalline powder. It is usually odorless and is light-sensitive, turning dark upon prolonged exposure to light. Proper storage away from light is necessary to preserve its appearance and efficacy.

Comment on solubility

Solubility of 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one

The solubility of the compound 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one is influenced by several factors due to its complex structure and functional groups. Here are some insights into its solubility:

  • Polar vs. Nonpolar: The presence of the dimethylamino group enhances the compound's polarity, which could lead to improved solubility in polar solvents such as water.
  • Hydrophobic Components: However, the phenothiazine structure contains hydrophobic characteristics that may hinder solubility in highly polar environments.
  • Solvent Compatibility: The compound may demonstrate better solubility in organic solvents like ethanol or DMSO, given its nonpolar segments.
  • Temperature Dependence: Temperature may also significantly affect solubility; typically, an increase in temperature can enhance solubility for many organic compounds.

Overall, while the structural features of 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one suggest it will have varying solubility depending on the solvent, the intriguing balance between hydrophilic and hydrophobic properties advocates for a robust study of its solubility profile in different mediums.

Interesting facts

Interesting Facts About 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one

This compound belongs to the phenothiazine class, which is notable for its pivotal role in medicinal chemistry, especially as antipsychotic medications. Below are some intriguing facts about this complex structure:

  • Multifunctionality: The presence of a dimethylamino group suggests potential for various physiological activities, making it a point of interest in drug design.
  • Therapeutic Applications: Compounds like this one may exhibit characteristics that influence neurotransmitter systems, which are critical in treating mental health disorders.
  • Structural Complexity: The integration of a phenothiazine moiety with a propanone group reflects a sophisticated approach in organic synthesis that aims to increase biological efficacy.
  • Research Interest: Given its structural features, this compound could be a valuable subject for research into medicinal properties and mechanisms of action.
  • Historical Context: The phenothiazine scaffold has a long history, first being recognized in the early 20th century for its utility in hospital settings, particularly in the field of psychiatry.

As one delves deeper into the chemistry of this compound, it becomes apparent that its design can potentially lead to innovations in pharmacotherapy. The intertwining of intricate groups contributes to its unique reactivity and biological interactions, making it a compelling topic of study for both chemists and pharmacologists alike.


Synonyms
Propionylpromazine
Propiopromazine
EINECS 222-662-1
UNII-Y1BCT334I7
PROPIONYLPROMAZIME
1-[10-[3-(DIMETHYLAMINO)PROPYL]-10H-PHENOTHIAZIN-2-YL]PROPAN-1-ONE
3-Propionyl-10-(3'-dimethylaminopropyl)phenothiazin
PROPIONYLPROMAZINE [MI]
DTXSID3046950
PROPIONYLPROMAZINE [MART.]
1-(10-(3-(Dimethylamino)propyl)-10H-phenothiazin-2-yl)propan-1-one
10-(3-Dimethylaminopropyl)-2-propionylphenothiazine
2-Propionyl-10-(3-Dimethylaminopropyl)phenothiazine
Combolen
PROPIONYLPROMAZINE (MART.)
1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one
DTXCID1026950
zqtvcqijtreksp-uhfffaoysa-n
Propionpromazine
Propionylpromazone
Combilen
2-Propionylpromazine
3568-24-9
Bayer 188
BAY 188
1497CB
Y1BCT334I7
1-(10-(3-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone
1-Propanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-
1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
1-Propanone, 1-(10-(3-(dimethylamino)propyl)phenothiazin-2-yl)-
1-Propanone, 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]-
1-Propanone, 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
1-[10-(3-dimethylaminopropyl)phenothiazin-2-yl]propan-1-one hydrochloride
NCGC00015838-03
Lopac-P-7780
Lopac0_000992
Oprea1_305223
CHEMBL41169
SCHEMBL1150446
CCG-205072
DB11540
SDCCGSBI-0050965.P002
NCGC00015838-01
NCGC00015838-02
NCGC00015838-04
NCGC00015838-08
NCGC00162309-01
NCGC00162309-02
DA-66933
NS00004016
Q27294135
1-(10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl)-1-propanone #