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Hydrocortisone

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
1-[(17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-hydroxy-ethanone
State
State
At room temperature, hydrocortisone is a solid.
Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
561.00
Boiling point (Kelvin)
834.15
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.3100g/cm3
Appearence

Hydrocortisone typically appears as a white or almost white, crystalline powder. It is odorless and stable under normal conditions.

Comment on solubility

Solubility of 1-[(17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-hydroxy-ethanone

The solubility of this complex organic compound can be quite intriguing, primarily influenced by its molecular structure and functional groups. Here are some key points regarding its solubility:

  • Hydroxyl Groups Effect: The presence of two hydroxyl groups in this compound typically enhances its solubility in polar solvents, such as water and alcohols. Hydroxyl groups can form hydrogen bonds, which generally increases solubility.
  • Hydrophobic Regions: Conversely, the tetradecahydrocyclopenta[a]phenanthrene moiety suggests a hydrophobic character due to large hydrocarbon chains. This can limit solubility in polar solvents, making this compound more soluble in non-polar solvents like oils or organic solvents such as ether and chloroform.
  • Temperature Dependency: Solubility is often temperature-dependent. Higher temperatures may increase the solubility of this compound in certain solvents, allowing it to dissolve more readily.
  • pH Influence: The solubility may also change with pH variations, particularly because of the hydroxyl groups. At lower pH levels, protonation might influence its solubility in aqueous solutions.

In conclusion, the solubility of this compound is a balance of its hydrophilic and hydrophobic features. As a rule of thumb, like dissolves like: the compound is likely to be soluble in polar solvents due to its hydroxyl groups, but might face challenges in strictly aqueous environments due to its bulky hydrophobic structure. Thorough solubility testing under various conditions would provide a more comprehensive understanding of its behavior in different solvents.

Interesting facts

Interesting Facts about 1-[(17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-hydroxy-ethanone

This compound, often referred to by its systematic name, is a fascinating molecule with significant biological relevance, particularly in the field of medicinal chemistry. Its intricate structure boasts a complex arrangement of multiple hydroxyl and alkyl groups, which contributes to its unique properties. Here are some key points to consider:

  • Biological Significance: This compound is classified as a potential steroid precursor, suggesting that it may play a vital role in the biosynthesis of steroids, which are crucial for various biological processes.
  • Complex Structure: The presence of multiple chiral centers and a bicyclic structure makes this compound a prime subject of study in stereochemistry, influencing how it interacts with biological targets.
  • Synthetic Interest: The synthesis of such compounds remains a topic of interest for organic chemists, as the challenge lies in constructing the molecular framework while ensuring the correct stereochemistry.
  • Potential Applications: Given its structure, it could hold promise for therapeutic applications, potentially leading to the development of new drugs with specific hormonal functions or action mechanisms.

In exploring this compound, scientists are not only unraveling its chemical properties but also discovering its potential implications in health and disease. This emphasizes the importance of organic and medicinal chemistry in developing new treatments. As the field evolves, compounds like this one could pave the way for future innovations in pharmacology.