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Vancomycin

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Identification
Molecular formula
C66H75Cl2N9O24
CAS number
1404-90-6
IUPAC name
1-[19-amino-7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[4-amino-1-[(2-amino-2-oxo-ethyl)carbamoyl]butyl]pyrrolidine-2-carboxamide
State
State

Vancomycin is a solid at room temperature and is typically provided as a powder that can be reconstituted into a liquid for medical use.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
78.50
Boiling point (Kelvin)
351.65
General information
Molecular weight
1449.26g/mol
Molar mass
1 449.2570g/mol
Density
1.3000g/cm3
Appearence

Vancomycin appears as a white to off-white crystalline powder. It is hygroscopic and usually provided as a hydrochloride salt which is soluble in water.

Comment on solubility

Solubility of 1-[19-amino-7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[4-amino-1-[(2-amino-2-oxo-ethyl)carbamoyl]butyl]pyrrolidine-2-carboxamide

The solubility of this complex compound can be quite challenging to determine due to its intricate structure and the various functional groups present. Here are some important considerations:

  • Hydrophobic vs. Hydrophilic Groups: The compound contains both hydrophilic amino and carbonyl groups, contributing to potential solubility in polar solvents, while the hydrophobic sections could hinder solubility.
  • Solvent Choice: Solubility can significantly vary depending on the solvent utilized. Water, for instance, might dissolve the compound to a degree, but organic solvents could be more effective.
  • pH Dependency: The solubility could be pH-dependent, with variations in solubility observed under acidic versus basic conditions.
  • Concentration Factors: It's vital to consider the concentration of the compound, as higher concentrations may lead to solubility limits being reached.

Understanding the solubility of such a compound is crucial for applications in pharmaceutical and chemical research. In the words of chemists, "Solubility is not just a property; it is the gateway to functionality." Thus, further studies are warranted to elucidate the specific solubility parameters of this compound.

Interesting facts

Interesting Facts About 1-[19-amino-7-(2-amino-2-oxo-ethyl)-10-(3-amino-3-oxo-propyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[4-amino-1-[(2-amino-2-oxo-ethyl)carbamoyl]butyl]pyrrolidine-2-carboxamide

This complex compound is an intriguing example of contemporary medicinal chemistry and drug design. Its elaborate structure reflects the meticulous nature of bioactive compound synthesis aimed at therapeutic applications. Here are some notable points about this fascinating molecule:

  • Structural Diversity: The compound features a unique multi-ring framework along with multiple functional groups, allowing for a diverse range of biochemical interactions.
  • Potential Therapeutics: Many compounds of similar architecture are being investigated for their potential as anticancer agents due to their ability to target specific cellular pathways.
  • Targeting Mechanism: The presence of amino groups may enhance its ability to interact with biological macromolecules like proteins and nucleic acids, possibly aiding in enzyme inhibition or activation.
  • Side Effects Exploration: Understanding the structure-function relationship of such compounds is pivotal in minimizing side effects and improving efficacy in therapeutic applications.
  • Innovation in Drug Design: This compound exemplifies the trend towards designing multi-target drugs which can simultaneously interact with different biological sites, thereby offering solutions for complex diseases.

As a researcher or student, delving into the synthesis and properties of such compounds not only enriches our chemical knowledge but also broadens our understanding of the intricate relationship between structure and biological activity. "Interested students should always explore the potential of new compounds; they often hold the key to revolutionary treatments."


The exploration of such an elaborate compound is a testament to the advances being made in pharmacology and organic chemistry, pushing the boundaries on how we can potentially treat diseases in the future.

Synonyms
POR-8;POR 8;POR8
SCHEMBL1650220
BCP10596
AKOS015896033
N-[5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
F85428