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Histamine

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Identification
Molecular formula
C5H9N3
CAS number
51-45-6
IUPAC name
1-(1H-imidazol-5-yl)propan-2-amine
State
State

At room temperature, histamine is generally in a solid state when pure. It appears in crystalline form which may be used for laboratory and synthetic applications.

Melting point (Celsius)
83.00
Melting point (Kelvin)
356.20
Boiling point (Celsius)
209.50
Boiling point (Kelvin)
482.70
General information
Molecular weight
111.15g/mol
Molar mass
111.1530g/mol
Density
1.1000g/cm3
Appearence

Histamine is typically encountered in the form of a colorless crystalline solid. In commercial and industrial contexts, it may also be encountered dissolved in an aqueous solution.

Comment on solubility

Solubility of 1-(1H-imidazol-5-yl)propan-2-amine (C5H9N3)

This compound exhibits interesting solubility characteristics, influenced by its structural properties. Solubility is a critical aspect that affects various applications, including pharmacology and chemical synthesis.

Key Points on Solubility:

  • Polarity: The presence of both amine and imidazole functional groups enhances its polarity, which typically increases its solubility in polar solvents.
  • Solvent Compatibility: It is likely to be soluble in water and other polar solvents, while having limited solubility in non-polar solvents.
  • Effect of pH: The solubility may vary with pH due to the protonation of the amine group, which could facilitate greater interaction with water molecules.
  • Concentration Dependence: As with many compounds, higher concentrations may lead to saturation, thus limiting solubility if the solution exceeds a certain threshold.

In summary, the solubility of 1-(1H-imidazol-5-yl)propan-2-amine is notably affected by its functional groups, making it an intriguing compound for further study. Determining its solubility in various conditions can provide valuable insights for practical applications.

Interesting facts

Interesting Facts about 1-(1H-imidazol-5-yl)propan-2-amine

1-(1H-imidazol-5-yl)propan-2-amine, also known by its shortened name, is a fascinating compound that plays a significant role in medicinal chemistry and biochemistry due to its unique structure.

Key Features:

  • Imidazole Ring: This compound features an imidazole moiety, which is known for its presence in numerous biological molecules, including the amino acid histidine. The imidazole ring is critical in enzyme active sites and plays a vital role in various biochemical reactions.
  • Potential Biological Activity: Compounds containing the imidazole structure have shown promise in developing pharmaceuticals that may act as antifungal, antimicrobial, and anticancer agents. Researchers are continuously studying the biological implications of this compound.
  • Amine Interaction: The propan-2-amine part of the molecule contributes to its basicity, allowing for interactions with acids and other negatively charged species, which enhances its biological activity.

In the realm of research, scientists are particularly interested in how variations of this compound can lead to improved therapeutic agents. The modification of the imidazole ring or the propan-2-amine group can alter the compound's efficacy and specificity in biological systems.

A notable quote in the scientific community captures the essence of modifying compounds like this one: "The structure of a compound dictates its function, and understanding both can lead to groundbreaking developments in science."

Applications in Research:

  • Drug Design: Used as a scaffold for novel drug development.
  • Biochemical Studies: Helpful in understanding enzyme mechanisms involving imidazole.
  • Therapeutic Investigations: Studied for potential treatment pathways in various diseases.

Overall, 1-(1H-imidazol-5-yl)propan-2-amine serves as an important example of how small structural elements in organic chemistry can lead to significant advancements in health sciences and biotechnology.

Synonyms
alpha-Methylhistamine
6986-90-9
1-(1h-imidazol-5-yl)propan-2-amine
1-(1h-imidazol-4-yl)propan-2-amine
2-(1H-Imidazol-4-yl)-1-methyl-ethylamine
1H-Imidazole-5-ethanamine,a-methyl-
CHEBI:74759
.alpha.-Methylhistamine
1H-Imidazole-4-ethanamine, alpha-methyl-
1H-Imidazole-4-ethanamine, .alpha.-methyl-
4-(2-Aminopropyl)imidazole
SCHEMBL396350
CHEMBL116655
NIOSH/NI3506300
SCHEMBL12328968
Imidazole, 4-(2-aminopropyl)-
DTXSID80990132
XNQIOISZPFVUFG-UHFFFAOYSA-N
PDSP1_000182
PDSP2_000181
AKOS012051956
SB38376
1-(1H-Imidazol-4-yl)-2-propanamine #
CS-0455026
NI35063000
NS00014783
EN300-254952
L000527
Q4734911