Skip to main content

1-(1H-Indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine

ADVERTISEMENT
Identification
Molecular formula
C16H11F3N2
CAS number
244236-46-6
IUPAC name
1-(1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine
State
State
The compound is generally in a solid state at room temperature, appearing as crystalline solids. Its consistent form and robust nature make it suitable for various chemical applications.
Melting point (Celsius)
142.50
Melting point (Kelvin)
415.70
Boiling point (Celsius)
315.50
Boiling point (Kelvin)
588.70
General information
Molecular weight
298.27g/mol
Molar mass
298.2900g/mol
Density
1.2670g/cm3
Appearence

This compound is typically found as a crystalline solid. Its color can vary from white to pale yellow, depending on purity and handling.

Comment on solubility

Solubility of 1-(1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine

The solubility of 1-(1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine exhibits notable characteristics due to its complex molecular structure. This compound, which contains both an indole and a trifluoromethyl group, demonstrates unique interactions with solvents.

Factors Influencing Solubility

Several factors affect the solubility of this compound:

  • Polarity: The presence of the trifluoromethyl group can increase non-polar interactions, potentially making the compound less soluble in polar solvents.
  • Hydrogen Bonding: The indole ring can participate in hydrogen bonding, which may enhance solubility in protic solvents.
  • Molecular Weight: The larger molecular size may hinder solubility to some extent, especially in less polar environments.

General Solubility Profile

Typically:

  • It may show moderate solubility in organic solvents such as methanol and dichloromethane.
  • Its solubility in water is likely to be limited due to hydrophobic regions of the molecule.
  • In general, compounds with similar structural features often require organic solvents for dissolution.

In summary, the solubility of 1-(1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine is shaped by its specific chemical characteristics and interactions. Understanding these factors is crucial for applications in various chemical processes.

Interesting facts

Interesting Facts about 1-(1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine

This intriguing compound, often referred to as a sophisticated chemical structure in the realm of medicinal chemistry, showcases an intriguing blend of organic features. Here are some captivating aspects:

  • Dual Origin: The compound features an indole structure, a bicyclic compound known for its presence in many natural products and pharmaceuticals, particularly in the context of drug development.
  • Trifluoromethyl Group: The presence of the trifluoromethyl group (-CF3) adds unique properties, such as increased lipophilicity, which can significantly enhance the bioavailability of compounds in drug formulation.
  • Applications in Drug Design: Due to its structural composition, this compound can be a precursor or a catalyst in synthesizing more complex molecules, proving valuable in the pharmaceutical industry.
  • Biological Activity: Compounds with indole structures have been widely studied for their various biological activities, including anti-cancer, anti-inflammatory, and analgesic properties, making this compound a subject of interest for researchers.
  • Research Potential: Ongoing studies may reveal further insights into the compound’s activity, interactions with biological systems, and potential therapeutic applications, further broadening its significance in scientific research.

Overall, 1-(1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine is an excellent example of how complex organic structures can lead to significant advancements in medicinal chemistry and pharmaceutical sciences. This compound is not just limited in application; its potential continues to inspire scientists seeking to unravel the mysteries of molecular interactions in living systems.

Synonyms
3-(N-(m-Trifluoromethylphenyl)formimidoyl)indole
22394-37-2
1-(1H-indol-3-yl)-N-[3-(trifluoromethyl)phenyl]methanimine
BRN 1484362
Indole, 3-(N-(m-trifluoromethylphenyl)formimidoyl)-
INDOLE, 3-(N-(alpha,alpha,alpha-TRIFLUORO-m-TOLYL)FORMIMIDOYL)-
CBDivE_000188
SCHEMBL18463770
XLDXPJATSYYKQB-AWQFTUOYSA-N
STL598238
AKOS037447888
N-[(E)-1H-indol-3-ylmethylidene]-3-(trifluoromethyl)aniline
N-[(E)-1-(1H-INDOL-3-YL)METHYLIDENE]-N-[3-(TRIFLUOROMETHYL)PHENYL]AMINE