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Ivermectin

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Identification
Molecular formula
C48H74O14
CAS number
70288-86-7
IUPAC name
1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
State
State

At room temperature, ivermectin is a solid. It is stable under normal conditions of use and storage.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
751.60
Boiling point (Kelvin)
1 024.80
General information
Molecular weight
873.18g/mol
Molar mass
873.1760g/mol
Density
1.2200g/cm3
Appearence

Ivermectin is a white to yellowish-white powder. It is often found in crystalline solid form, without any characteristic odor.

Comment on solubility

Solubility of 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

The solubility of complex compounds such as 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate can be influenced by a variety of factors, making it a fascinating topic for study. Here are key points regarding its solubility:

  • Polarity: The presence of hydroxyl groups suggests a degree of polarity, which may enhance solubility in polar solvents such as water.
  • Hydrophobic regions: The complex hydrocarbon structure may indicate hydrophobic characteristics, potentially decreasing solubility in aqueous environments.
  • Functional groups: The carboxylate group presents in this compound could interact favorably with water, enhancing solubility.
  • Solvent interactions: This compound's solubility may vary in organic solvents compared to water, possibly showing higher solubility in non-polar solvents due to its intricate hydrophobic regions.

In summary, the solubility of this compound is likely to be influenced by a delicate balance between its polar and non-polar characteristics. Understanding its solubility profile can be crucial for developing formulations and applications in various fields.

Interesting facts

Interesting Facts about 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

This complex compound is a fascinating example of how intricate chemical design and modification can lead to unique properties and potential applications. Here are some engaging aspects to consider:

  • Structural Diversity: The compound features a hexacyclic structure, which indicates its potential for diverse stereochemistry and complex interactions with biological systems.
  • Natural Product Inspiration: Many compounds resembling this structure have roots in natural products, which are known for their biological activity. This compound could be a synthetic derivative aimed at enhancing such bioactivity.
  • Potential Applications: Its intricate molecular framework suggests uses in medicinal chemistry, perhaps as an antibiotic or anti-inflammatory drug. The tailored side chains indicate the possibility of modulating its activity and selectivity.
  • Research Interest: Due to its structural complexity, this molecule invites research into synthetic methodologies that could streamline its production, opening avenues in both academic and industrial chemistry.
  • Interdisciplinary Appeal: The study of such compounds bridges multiple fields, including pharmacology, organic synthesis, and medicinal chemistry, emphasizing the importance of cross-disciplinary collaboration in modern science.

In conclusion, the study of 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate not only challenges our understanding of organic synthesis but also reminds us of the potential to discover new therapeutic agents through the exploration of complex chemical structures. As one noted chemist said, "Every molecule has a story; it's our job to unravel it."

Synonyms
SCHEMBL660466