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Erythromycin A

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Identification
Molecular formula
C37H67NO13
CAS number
114-07-8
IUPAC name
1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,5-dimethyl-1H-pyrrole-3-carboxylate
State
State

Erythromycin A is typically found in a solid state at room temperature. As a crystalline powder, it has a stable solid form that is essential for its utilization in pharmaceutical formulations.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
876.60
Boiling point (Kelvin)
1 149.80
General information
Molecular weight
733.94g/mol
Molar mass
733.9370g/mol
Density
1.2447g/cm3
Appearence

Erythromycin A appears as a white to off-white crystalline powder. It is commonly available in its anhydrous or semihydrate form, although it can also be present as a dihydrate. When exposed to light, it may gradually become yellowed. It is slightly soluble in water and more soluble in alcohol, chloroform, and ether.

Comment on solubility

Solubility of 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,5-dimethyl-1H-pyrrole-3-carboxylate

Understanding the solubility of complex organic compounds like 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,5-dimethyl-1H-pyrrole-3-carboxylate is essential for their application in various fields, such as pharmaceuticals and materials science. The solubility of this compound can be influenced by several factors:

  • Molecular Structure: The presence of multiple functional groups can affect solubility, with hydroxyl (-OH) groups often enhancing the interaction with polar solvents.
  • Solvation Effects: How the solvent molecules interact with the compound plays a crucial role. For example, solvents like water may dissolve compounds with polar character better than non-polar solvents.
  • Temperature: Increasing temperature generally increases solubility for many organic compounds due to enhanced molecular motion.
  • pH: The acidity or basicity of a solution can significantly alter the ionization state of the compound, which can either enhance or decrease solubility.

In summary, the solubility of 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,5-dimethyl-1H-pyrrole-3-carboxylate is a complex interplay of its structural components and the environment in which it is placed. Thus, a thorough examination of its solubility characteristics is imperative for its optimal utilization.

Interesting facts

Exploring the Fascinating Compound: 1-[(1R,5R,6S,9S,12R)-9,12-dihydroxy-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-dien-22-yl]ethyl 2,5-dimethyl-1H-pyrrole-3-carboxylate

This compound represents a complex architecture of organic chemistry, showcasing the beauty and intricacy found within molecular design. Its structure is characterized by multiple rings and functional groups, which often lead to unique biological activities. Here are some intriguing aspects of this compound that underscore its significance in the field of chemistry:

  • Diverse Functional Groups: The presence of hydroxyl and carboxylate functional groups can result in interesting interactions with biological systems, potentially offering medicinal properties.
  • Anabolic Potential: Compounds with similar frameworks are often explored for their anabolic properties, making them of interest in medicinal and agricultural chemistry.
  • Complex Ring Structure: The hexacyclic core hints at its potential activity in mimicking natural products, which are frequently utilized in drug development.
  • Aromatic Contributions: The presence of pyrrole in the side chain introduces nitrogen heterocycles that can affect the compound's reactivity and interaction with other molecules.
  • Stereochemistry Significance: The stereochemical configuration of this compound could influence its pharmacokinetics and pharmacodynamics, which are critical considerations in drug design.

In the words of renowned chemists, "The joy of chemistry is the discovery of the unexpected." This compound indeed represents the potential for serendipitous discovery in future research endeavors. Its structural complexity may lead to significant breakthroughs in understanding biochemical pathways or developing new therapeutic agents.

Overall, this compound stands as a testament to the innovative possibilities found in organic synthesis and the enduring quest for new chemical entities that can benefit various fields from pharmaceuticals to agriculture.

Synonyms
BRN 1613384
23756-88-9
Batrachotoxinin A, 20-(2,5-dimethyl-1H-pyrrole-3-carboxylate)
BATRACHOTOXININ A, 20-(2,5-DIMETHYLPYRROLE-3-CARBOXYLATE)
RefChem:320979
DTXSID40946539
1-(9,12-Dihydroxy-2,11a-dimethyl-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-7H-9,11b-epoxy-13a,5a-prop[1]enophenanthro[2,1-f][1,4]oxazepin-14-yl)ethyl 2,5-dimethyl-1H-pyrrole-3-carboxylate