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Vesnarinone

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Identification
Molecular formula
C20H26N2O2
CAS number
81840-15-5
IUPAC name
1-[2-(1-piperidyl)propyl]-3,4-dihydroquinolin-2-one
State
State

At room temperature, vesnarinone is found in a solid state.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
338.00
Boiling point (Kelvin)
611.15
General information
Molecular weight
364.47g/mol
Molar mass
364.4720g/mol
Density
1.2300g/cm3
Appearence

Vesnarinone typically appears as a white to off-white crystalline powder. It is usually odorless and has a bitter taste.

Comment on solubility

Solubility of 1-[2-(1-piperidyl)propyl]-3,4-dihydroquinolin-2-one

The solubility of 1-[2-(1-piperidyl)propyl]-3,4-dihydroquinolin-2-one is influenced by various factors due to its molecular structure. Understanding its solubility is crucial for its application in pharmaceutical processes and formulations.

Factors Affecting Solubility

  • Molecular Structure: The presence of the piperidyl group can enhance solubility in polar solvents, while the quinoline structure generally exhibits greater lipophilicity.
  • Polarity: The balance between hydrophobic (non-polar) and hydrophilic (polar) regions plays a significant role in how well this compound dissolves in various solvents.
  • Temperature: Solubility tends to increase with temperature; thus, higher temperatures may aid in achieving better dissolution for this compound.
  • pH Level: The solubility may also vary with changes in pH due to potential ionization of functional groups under different conditions.

General Observations

In practice, it is key to assess 1-[2-(1-piperidyl)propyl]-3,4-dihydroquinolin-2-one's solubility in common solvents, which can include:

  • Water
  • Alcohols (e.g., ethanol, methanol)
  • Dimethyl sulfoxide (DMSO)
  • Dimethylformamide (DMF)

As a conclusion, evaluating the solubility of this compound in different environments is essential for determining its effectiveness in various applications. Failing to consider these factors could lead to decreased efficacy in pharmaceutical formulations and biological interactions.

Interesting facts

Interesting Facts about 1-[2-(1-piperidyl)propyl]-3,4-dihydroquinolin-2-one

1-[2-(1-piperidyl)propyl]-3,4-dihydroquinolin-2-one is a fascinating compound that has drawn the attention of researchers due to its potential applications in medicinal chemistry. Here are some noteworthy aspects:

  • Structural Diversity: The unique structure of this compound incorporates a piperidine ring, which is significant in facilitating interactions with biological targets. This connectivity often enhances its pharmacological properties.
  • Biological Activity: Compounds featuring the quinolinone core are known for a variety of biological activities, including antimicrobial and anticancer properties. Research is ongoing to explore how this specific configuration can be optimized for therapeutic use.
  • Neuropharmacological Potential: Due to the presence of the piperidine moiety, this compound may influence neurotransmitter systems, offering possibilities in treating neurological disorders. Many piperidine derivatives have been studied for their efficacy in modulating behavior and cognition.
  • Synthesis Challenges: The synthesis of this compound can be quite complex, involving multiple steps that require careful control of reaction conditions. This complexity can sometimes limit the scale of production, but also offers a rich area for chemists to innovate new routes of synthesis.
  • Research Frontiers: Current research efforts are focusing on understanding the mechanism of action and optimizing pharmacokinetics, which could result in more effective medicinal compounds based on its structure.

In summary, 1-[2-(1-piperidyl)propyl]-3,4-dihydroquinolin-2-one serves as an intriguing example of how structural nuances can lead to diverse and potentially impactful biological activities. As we continue to explore compounds like this one, we unlock new avenues for drug discovery and therapeutic advancements.

Synonyms
BRN 1541462
3,4-Dihydro-1-(2-piperidinopropyl)carbostyril
3305-32-6
CARBOSTYRIL, 3,4-DIHYDRO-1-(2-PIPERIDINOPROPYL)-
5-21-08-00059 (Beilstein Handbook Reference)
DTXSID20954677
1-[2-(piperidin-1-yl)propyl]-3,4-dihydroquinolin-2(1H)-one