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Fexofenadine

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Identification
Molecular formula
C32H39NO4
CAS number
83799-24-0
IUPAC name
1-[2-(2-benzylphenoxy)-1-methyl-ethyl]piperidine
State
State

At room temperature, fexofenadine is a solid.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.20
Boiling point (Celsius)
495.90
Boiling point (Kelvin)
769.00
General information
Molecular weight
501.66g/mol
Molar mass
501.6620g/mol
Density
1.2100g/cm3
Appearence

At room temperature, fexofenadine appears as a white to off-white crystalline powder. It is practically insoluble in water and freely soluble in methanol and ethanol.

Comment on solubility

Solubility Analysis of 1-[2-(2-benzylphenoxy)-1-methyl-ethyl]piperidine

The compound 1-[2-(2-benzylphenoxy)-1-methyl-ethyl]piperidine, with the chemical formula C32H39NO4, presents an intriguing profile regarding its solubility characteristics. Understanding the solubility of this compound hinges on the presence of functional groups and the overall molecular structure.

Key Factors Affecting Solubility:

  • Hydrophobic Character: The compound features a significant hydrophobic moiety due to the large benzylphenoxy group, which tends to limit solubility in polar solvents like water.
  • Polar Functional Groups: The presence of the nitrogen atom in the piperidine ring could enhance solubility in certain polar solvents, potentially facilitating interaction through hydrogen bonding.
  • Chain Length: The long aliphatic chain attached to the piperidine plays a role in solubility, impacting the overall polarity and solubility profile of the molecule.

This compound is likely to exhibit:

  1. Low solubility in water: Due to the predominantly hydrophobic character and the bulky structure.
  2. Better solubility in organic solvents: Such as ethanol, methanol, and acetone, where the molecular interactions can be more favorable.
  3. Potential for biochemical solubility: In lipid matrices, which is critical for pharmacological applications.

As noted in solubility studies, "like dissolves like," meaning that the non-polar nature of the compound aligns it more closely with organic solvents than with polar solvents, further indicating the importance of understanding its solubility in various contexts.

Interesting facts

Exploring 1-[2-(2-benzylphenoxy)-1-methyl-ethyl]piperidine

1-[2-(2-benzylphenoxy)-1-methyl-ethyl]piperidine is a fascinating compound in the realm of organic chemistry, particularly due to its unique structural features and potential applications. Here are some interesting facts about this compound:

  • Structural Complexity: The compound contains a piperidine ring, which is a six-membered ring with nitrogen, adding a layer of chemical complexity.
  • Functional Groups: This piperidine derivative integrates various functional groups, such as ethers and aromatic rings, which can lead to intriguing reactivity and interaction profiles in biological systems.
  • Potential Applications: Compounds of this nature are often investigated for their use in pharmaceuticals. The distinct structure could lend itself to potential applications in neurology and psychiatry as drug candidates.
  • Research Focus: Scientists are particularly interested in the role of the benzylphenoxy moiety, as it may influence the compound's binding affinity to specific receptors, making it a possible candidate for drug design.

As you delve deeper into the study of compounds like 1-[2-(2-benzylphenoxy)-1-methyl-ethyl]piperidine, consider the significance of structure-function relationships in medicinal chemistry. Understanding how modifications in a compound's structure can alter its biological activity is key to developing new medications.

In summary, the piperidine derivatives like this one not only exhibit structural elegance but also the potential for significant impact in the fields of chemistry and pharmaceuticals.

Synonyms
Benproperine
2156-27-6
Cofrel
Pirexyl
Benproperine [INN]
benproperina
Bemproperina
Benproperinum
1-(2-(2-Benzylphenoxy)-1-methylethyl)piperidine
Benproperinum [INN-Latin]
Bemproperina [INN-Spanish]
3AA6IZ48YK
Cofrel (TN)
Benproperine (INN)
BENPROPERINE [MI]
ASA 158/5 [AS PHOSPHATE]
UNII-3AA6IZ48YK
BRN 1258822
BENPROPERINE [MART.]
BENPROPERINE [WHO-DD]
ASA 158/5 FREE BASE
ASA-158/5 FREE BASE
1-[1-(2-benzylphenoxy)propan-2-yl]piperidine
DTXSID10862853
1-(1-Methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)piperidine
1-(2-(2-Benzilfenossi)-1-metiletil)-piperidina [Italian]
Piperidine, 1-(1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-
Piperidine, 1-(1-methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)-
ASA 158-5
Benproperinum (INN-Latin)
Bemproperina (INN-Spanish)
1-(2-(2-Benzilfenossi)-1-metiletil)-piperidina
BENPROPERINE (MART.)
5-20-02-00159 (Beilstein Handbook Reference)
ASA 158/5 (AS PHOSPHATE)
1-(1-(2-benzylphenoxy)propan-2-yl)piperidine
1-[2-(2-benzylphenoxy)-1-methylethyl]piperidine
rac-1-(1-(2-benzylphenoxy)propan-2-yl)piperidine
rac-1-[1-(2-benzylphenoxy)propan-2-yl]piperidine
1-{1-methyl-2-[(alpha-phenyl-o-tolyl)oxy]ethyl}piperidine
Benproperin
benproper-inum
rac-benproperine
(+-)-benproperine
PIPERIDINE,1-[1-METHYL-2-[2-(PHENYLMETHYL)PHENOXY]ETHYL]-
SCHEMBL142207
CHEMBL2105910
CHEBI:37560
CHEBI:94380
DTXCID90811566
R05DB02
AKOS015962139
DB13309
MRF-0000197
AC-15848
NS00000607
D07512
AB00698314-05
1-(o-benzylphenoxy)-2-piperidinopropane phosphate
Q818139
BRD-A42423104-001-01-4
1-((1R)-1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-piperidine
1-((1S)-1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-piperidine
Piperidine, 1-(1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-(9CI)