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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
1-[2-[2-(diethylamino)ethoxy]phenyl]ethanone
State
State

At room temperature, lidocaine is typically a crystalline solid. It has a neutral pH in water and demonstrates significant solubility in organic solvents.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.20
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
624.00
General information
Molecular weight
235.34g/mol
Molar mass
235.3390g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is often found as a white to off-white crystalline powder. It is slightly soluble in water, but very soluble in ethanol, chloroform, and ether.

Comment on solubility

Solubility of 1-[2-[2-(diethylamino)ethoxy]phenyl]ethanone

The solubility of the compound 1-[2-[2-(diethylamino)ethoxy]phenyl]ethanone can be quite nuanced due to its molecular structure. Here are several key points to consider:

  • Polar vs. Non-Polar Solvents: Generally, this compound may exhibit better solubility in organic solvents due to its relatively non-polar character from the diethylamino group.
  • Hydrogen Bonding: The presence of the ethoxy group facilitates potential hydrogen bonding with suitable solvents, which can enhance solubility in polar organic solvents.
  • Temperature Effects: As with many organic compounds, increased temperature tends to improve solubility, allowing for greater interaction with solvent molecules.

It's important to note that solubility can vary significantly based on factors such as solute concentration, temperature, and the specific solvent system used. Always perform empirical testing to confirm solubility characteristics in practical applications.

Interesting facts

Interesting Facts about 1-[2-[2-(diethylamino)ethoxy]phenyl]ethanone

1-[2-[2-(diethylamino)ethoxy]phenyl]ethanone is a fascinating compound that showcases the complexity and diversity of organic chemistry. Here are some intriguing aspects of this compound:

  • Structure Diversity: This compound features a unique combination of functional groups, including an ethanone group and a diethylamino moiety, which highlight its potential for various chemical reactions.
  • Applications in Medicine: Compounds with a similar structure are often explored for their pharmacological properties. They may serve as valuable precursors in designing medications, particularly in the fields of analgesics and anti-inflammatory drugs.
  • Research Interest: The ethoxy group in the structure can enhance solubility and bioavailability, making this compound a subject of research interest in drug development and formulation chemistry.
  • Potential Side Effects: As with many compounds containing diethylamino groups, researchers must consider the potential for side effects and interactions during their investigation into therapeutic uses.
  • Versatile Synthetic Routes: The synthesis of such complex compounds often involves multiple steps, providing opportunities for creativity and innovation in synthetic chemistry methodologies.

This compound exemplifies how subtle variations in molecular structure can lead to significant differences in properties and applications, underlining the importance of molecular design in the field of chemistry.

Synonyms
ACETOPHENONE, 2'-(2-(DIETHYLAMINO)ETHOXY)-
2175-79-3
2'-(2-(Diethylamino)ethoxy)acetophenone
BRN 1968736
DTXSID70176145
NSC 359034
4-08-00-00323 (Beilstein Handbook Reference)
DTXCID5098636
1-[2-[2-(diethylamino)ethoxy]phenyl]ethanone
NSC359034
CHEMBL1619632
AKOS000184126
NSC-359034
NCGC00245678-01