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Loperamide Hydrochloride

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Identification
Molecular formula
C29H34ClN3O2
CAS number
34552-83-5
IUPAC name
1-[2-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one;chloride
State
State

At room temperature, Loperamide Hydrochloride is typically considered a solid. This is important for its handling, packaging, and formulation into dosage forms. Its solid state at ambient conditions ensures it remains stable during transport and storage.

Melting point (Celsius)
225.50
Melting point (Kelvin)
498.70
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.00
General information
Molecular weight
477.03g/mol
Molar mass
477.0340g/mol
Density
1.2000g/cm3
Appearence

Loperamide Hydrochloride typically appears as a white to off-white powder or crystalline substance. It is known for being very finely milled and can often form fluffy aggregates.

Comment on solubility

Solubility of 1-[2-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one;chloride

The solubility of 1-[2-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one;chloride is an intriguing topic due to its unique structural characteristics. This compound exhibits properties that can influence its solubility in various solvents:

  • Ionic Nature: The presence of the piperidine ring protonated at nitrogen contributes to its ionic nature, enhancing solubility in polar solvents like water.
  • Hydrophobic Interactions: The butanone and phenyl groups provide hydrophobic characteristics, which can make the compound less soluble in very polar or protic solvents.
  • Solvent Compatibility: It is expected to show better solubility in a mixture of polar and non-polar solvents, such as in ethanol or acetonitrile, due to the balance of hydrophilic and hydrophobic elements in its structure.

Considering these factors, it is important to highlight that the solubility of this compound can be affected by temperature and the specific type of solvents used. Furthermore, the ability to form hydrogen bonds with solvent molecules may also play a significant role in its overall solubility profile.

In summary, the solubility of 1-[2-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one;chloride is influenced by a combination of ionic interactions, hydrophobic effects, and compatibility with various solvent environments, making it a compound of considerable interest in the study of solution chemistry.

Interesting facts

Interesting Facts about 1-[2-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one; chloride

This compound, known as 1-[2-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one; chloride, is a fascinating example of a complex organic molecule exhibiting both pharmaceutical and biological significance. Here are some notable aspects:

  • Pharmaceutical Potential: This compound is often studied for its potential use in treating various neurological disorders due to its interaction with neurotransmitter systems.
  • Piperidine Backbone: The presence of a piperidine ring in the structure contributes to its ability to act as a feel-good neurotransmitter, which has implications for developing antidepressant and anxiolytic medications.
  • Electrophilic Nature: The butan-1-one moiety may enhance the compound's electrophilic properties, which can affect reactivity and interactions at the molecular level.
  • Research Interest: Its unique structural attributes make it a subject of interest in medicinal chemistry and drug design, particularly in the synthesis of new therapeutic agents.

In academic circles, there’s often a saying that captures the essence of such compounds: "Chemistry is the art of problem-solving at the molecular level." As research progresses, the implications of this compound and similar derivatives may become increasingly significant in the fields of pharmacology and neurochemistry.

Further studies may reveal deeper insights into efficacy, safety, and potential applications, making it a valuable subject for ongoing investigation within the scientific community.

Synonyms
2'-(2-Piperidinoethoxy)butyrophenone hydrochloride
20800-18-4
Butyrophenone, 6'-(2-piperidinoethoxy)-, hydrochloride
BUTYROPHENONE, 2'-(2-PIPERIDINOETHOXY)-, HYDROCHLORIDE
RefChem:331370