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Modafinil

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Identification
Molecular formula
C15H15Cl2NO2S
CAS number
68693-11-8
IUPAC name
1-[2-(3,4-dichlorophenyl)sulfinylethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, Modafinil is in a solid state. It is typically handled in powder form and is somewhat hygroscopic, meaning it can absorb moisture from the air.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.00
Boiling point (Celsius)
527.50
Boiling point (Kelvin)
800.50
General information
Molecular weight
273.36g/mol
Molar mass
273.3560g/mol
Density
1.4360g/cm3
Appearence

Modafinil typically appears as a white to off-white crystalline powder. It has a slightly bitter taste.

Comment on solubility

Solubility of 1-[2-(3,4-dichlorophenyl)sulfinylethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

The solubility of the compound 1-[2-(3,4-dichlorophenyl)sulfinylethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline may greatly vary depending on several factors. Here are some key points to consider:

  • Polarity: Given the presence of multiple methoxy groups and a sulfinyl moiety, the compound may exhibit moderate polarity. This can influence its solubility in polar solvents such as water or alcohols.
  • Solvent Compatibility: It is likely soluble in organic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), which can better accommodate the compound's structural features.
  • Temperature Dependency: Solubility may increase with temperature; thus, evaluating the solubility at various temperatures could provide further insights into its behavior in different environments.
  • pH Impact: The solubility can also be affected by pH levels, as the ionization of functional groups may promote or inhibit solubility in aqueous environments.

Understanding these aspects is crucial for determining the appropriate solvent systems for utilization in laboratory settings or pharmaceutical applications. As a chemist, one must always experiment to find the optimal conditions for dissolution.

Interesting facts

Interesting Facts About 1-[2-(3,4-Dichlorophenyl)sulfinylethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

The compound 1-[2-(3,4-dichlorophenyl)sulfinylethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline is a fascinating member of the isoquinoline family, known for its diverse biological activities. This compound stands out due to its unique structural features and potential applications in medicinal chemistry.

Key Features

  • Structural Complexity: The isoquinoline core combined with a sulfinyl group and a dichlorophenyl moiety contributes to the compound's intricate three-dimensional shape, which is vital for its interaction with biological targets.
  • Pharmacological Potential: Compounds structurally similar to this one have shown a range of pharmacological effects, including analgesic and anti-inflammatory properties, making them subjects of interest in drug development.
  • Sulfinyl Group Role: The presence of a sulfinyl group is notable as it can enhance **bioactivity** and potentially influence the binding affinity to specific receptors or enzymes in the body.

Research Highlights

Studies have indicated that derivatives of isoquinoline can serve as:

  • Antimicrobial agents: Their structural features may provide pathways for interaction with microbial cell components.
  • Neuroprotective agents: Investigations are ongoing to explore how isoquinoline derivatives can protect neurons and combat neurodegenerative diseases.
  • Antitumor compounds: Some isoquinoline-based structures have shown promise in inhibiting cancer cell growth.

As a potent example of how structural modifications can lead to enhanced biological activities, this compound opens the door for future research in the synthesis of new therapeutic agents. The combination of the sulfinyl and dichlorophenyl functionalities could warrant a deeper examination, leading to the discovery of novel mechanisms of action in various therapeutic areas.