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Dolasetron Mesylate

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Identification
Molecular formula
C19H20Cl2N2O5S
CAS number
115956-13-3
IUPAC name
1-[2-(3,4-dichlorophenyl)sulfonylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
State
State

At room temperature, dolasetron mesylate exists as a solid. It is stable under normal conditions and does not evaporate readily.

Melting point (Celsius)
124.00
Melting point (Kelvin)
397.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
438.34g/mol
Molar mass
438.3380g/mol
Density
1.6600g/cm3
Appearence

Dolasetron mesylate appears as a white to off-white crystalline powder. The compound is known for its solubility in water and alcohol, while being practically insoluble in heptane. Due to its crystalline nature, it might exhibit a distinct luster or sheen under certain lighting conditions.

Comment on solubility

Solubility of 1-[2-(3,4-dichlorophenyl)sulfonylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

The solubility of 1-[2-(3,4-dichlorophenyl)sulfonylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride can be an intriguing consideration, particularly with respect to its ionic form. Generally, compounds that possess ionic characteristics, such as this one due to its chloride component, tend to show enhanced solubility in polar solvents, primarily water. Here are some key points regarding its solubility:

  • Polarity: The molecule contains both hydrophobic (from the isoquinoline structure) and hydrophilic (the chloride ion and sulfonyl group) regions, suggesting that it may exhibit moderate to high solubility in water.
  • Protic Solvents: It is likely to be soluble in protic solvents, as the interactions with solvent molecules can assist in overcoming the lattice energy of the ionic compound.
  • Non-Polar Solvents: In contrast, the solubility in non-polar solvents is expected to be limited due to the presence of polar functionalities that do not interact well with non-polar environments.

In conclusion, one might say that the solubility of this compound is predominantly determined by its ionic nature and the balance between its polar and non-polar characteristics. Understanding these aspects can provide valuable insights for potential applications where solubility plays a critical role.

Interesting facts

Interesting Facts About 1-[2-(3,4-Dichlorophenyl)sulfonylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

This compound, often referred to in the field of pharmaceutical chemistry, presents a fascinating structure and potential applications. Here are some key points:

  • Pharmacological Interest: The unique combination of the isoquinoline structure with substituents such as 3,4-dichlorophenyl and sulfonyl groups makes this compound a potential candidate for drug development. Compounds with isoquinoline frameworks have shown a variety of biological activities including anti-cancer properties.
  • Mechanism of Action: The sulfonamide moiety present in this compound often acts as a versatile linking group that can enhance the bioactivity of the molecule, leading researchers to explore how it interacts with biological systems at a molecular level.
  • Synthetic Pathways: The synthesis of tetrahydroisoquinolines, like this compound, involves intricate multi-step reactions often starting from readily available precursors. The presence of dimethoxy groups can significantly influence the reactivity and stability of the molecule, presenting a delightful challenge for chemists.
  • Electrophilic Properties: The dichlorophenyl group not only improves the lipophilicity of the compound but also serves as a site for electrophilic substitution reactions, allowing chemists to further manipulate the structure to create analogues with possibly enhanced properties.

In summary, 1-[2-(3,4-dichlorophenyl)sulfonylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride exemplifies the intriguing crossroads of synthetic organic chemistry and medicinal research. Its complex structure rich with functional groups presents both challenges and opportunities for further investigation.

Synonyms
22309-31-5
Isoquinoline, 1-(2-((3,4-dichlorophenyl)sulfonyl)ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, hydrochloride
RefChem:349969