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Prochlorperazine

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Identification
Molecular formula
C20H25ClN3O2 · 2HCl
CAS number
84-02-6
IUPAC name
1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one;dihydrochloride
State
State

At room temperature, Prochlorperazine dihydrochloride is typically found as a solid.

Melting point (Celsius)
232.00
Melting point (Kelvin)
505.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
446.86g/mol
Molar mass
446.8570g/mol
Density
1.2740g/cm3
Appearence

Prochlorperazine dihydrochloride is a white or pale yellow crystalline powder. It is odorless or almost odorless and is hygroscopic, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one; dihydrochloride

The solubility profile of the compound 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one; dihydrochloride is an interesting subject that warrants exploration. Here are some key considerations:

  • Solvent Compatibility: This dihydrochloride salt form typically demonstrates increased solubility in polar solvents, such as water, due to the ionic nature imparted by the two chloride ions.
  • Ionization: In aqueous solutions, the ionization of the compound enhances its solubility. The presence of the dihydrochloride allows for better dissociation compared to its free base form.
  • Temperature Influence: Like many salts, the solubility may increase with temperature, allowing for more effective dissolution in higher-temperature aqueous solutions.
  • pH Dependence: The solubility can also be influenced by the pH of the solution. For instance, certain pH levels may promote or inhibit ionization, which directly affects solubility.

In summary, while the precise solubility characteristics of this compound can vary based on formulation and conditions, it generally benefits from enhanced aqueous solubility due to its dihydrochloride form. This property is critical for its performance in biological systems and pharmacological applications.

Interesting facts

Interesting Facts about 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one; dihydrochloride

This compound, often classified within the realm of medicinal chemistry, exhibits noteworthy characteristics that spark interest among researchers and students alike. Here are some fascinating points to consider:

  • Pharmaceutical Significance: This compound is part of a broader class of chemical substances that have been studied for their potential therapeutic effects, particularly in the treatment of psychiatric disorders.
  • Structural Complexity: The intricate structure of this compound reflects the interplay of multiple functional groups, contributing to its unique biological properties. This complexity can lead to diverse interactions within biological systems.
  • Mechanism of Action: Whereas specific mechanisms can vary, many compounds within this class are known to interact with neurotransmitter systems, making them valuable in neuropharmacology research.
  • Chlorophenothiazine Moiety: The presence of the 2-chlorophenothiazin moiety indicates potential antipsychotic activity, as phenothiazines are historically recognized for their neuroleptic properties.
  • Adaptable Derivatives: The ability to modify the nitrogen-containing ring structures allows for the design of derivatives, which can fine-tune the activity and reduce side effects, a critical concern in drug development.
  • Research Potential: Ongoing studies continue to explore the full range of this compound's applications and its effectiveness, alongside addressing challenges such as drug resistance and specificity.

In summary, 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one; dihydrochloride stands as a promising compound within the pharmaceutical industry, representing the intersection of chemical innovation and therapeutic advancement. Its structural nuances open up pathways for exploration in both academic research and clinical applications.

Synonyms
Ponsital
Imiclopazine dihydrochloride
7414-95-1
Imidazolidone dihydrochloride
Chlorimiphene dichloride
Imiclopazine HCl
Chlorimipiphenine dihydrochloride
ASTA P 4241
UNII-M8F5N05QB7
NSC 113426
M8F5N05QB7
NSC-113426
IMICLOPAZINE DIHYDROCHLORIDE [MI]
P-4241
2-Imidazolidinone, 1-(2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl)-3-methyl-, dihydrochloride
2-Imidazolidinone, 1-(2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl)-3-methyl-, dihydrochloride
1-(2-(4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHYL)-3-METHYL-2-IMIDAZOLIDINONE, DIHYDROCHLORIDE
2-IMIDAZOLIDINONE, 1-(2-(4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHYL)-3-METHYL-, HYDROCHLORIDE (1:2)
2-Imidazolidinone, 1-(2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl)-3-methyl-, dihydrochloride (9CI)
1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methylimidazolidin-2-one;dihydrochloride
AKOS040758322
AS-78248
DS-002660
HY-137088
CS-0136408
D93552
Q27283631