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Trimeprazine

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Identification
Molecular formula
C22H27ClN4OS
CAS number
516-79-8
IUPAC name
1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one
State
State

Trimeprazine is typically a solid at room temperature.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
419.70
Boiling point (Kelvin)
692.85
General information
Molecular weight
435.98g/mol
Molar mass
435.9670g/mol
Density
1.3800g/cm3
Appearence

Trimeprazine appears as a white to light yellow crystalline powder. It is often formulated as tartrate or other salts for different pharmaceutical applications.

Comment on solubility

Solubility of 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one

The solubility of the compound 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one can be quite complex due to its intricate molecular structure and various functional groups. Understanding its solubility potential is essential for its application in different environments.

Factors Influencing Solubility:

  • Polarity: The balance of polar and nonpolar regions within the molecule affects its solubility in aqueous versus organic solvents.
  • Functional Groups: The presence of chlorine and nitrogen-containing groups can enhance hydrogen bonding, influencing solubility behavior.
  • pH Levels: The molecule’s solubility may vary with changes in pH, impacting the ionization of its functional groups.

In general, compounds such as this with complex heteroatoms and aromatic structures are often characterized as having:

  • Variable solubility: They may dissolve better in organic solvents rather than in water.
  • Limited aqueous solubility: Due to potential aggregation or poor interaction with water.

Overall, while exact solubility can depend on specific conditions such as temperature and solvent type, one might expect that this compound is more soluble in organic media compared to water, making it suitable for certain pharmaceutical applications.

Interesting facts

Interesting Facts about 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one

This compound, with a complex structure and unique properties, stands out in the field of medicinal chemistry. It is a noteworthy member of a large family of pharmaceuticals known for their therapeutic potential.

Key Characteristics

  • Multi-functional role: This compound exhibits the ability to interact with various biological targets, making it valuable in designing new drugs.
  • Diverse applications: It can be explored for uses in treating conditions like schizophrenia and depression, owing to its psychoactive properties.
  • Structural diversity: The intricate arrangement of its atoms contributes to the compound's efficacy and specificity in biological systems.
  • Research interest: Ongoing studies into its pharmacodynamics and pharmacokinetics continue to uncover new therapeutic avenues.

Notable Features

Here are some fascinating aspects of this compound:

  • Chlorophenothiazine moiety: The incorporation of the 2-chlorophenothiazin-10-yl group allows for enhanced interactions with neurotransmitter receptors.
  • Piperazine link: The piperazine segment is known for its ability to improve solubility and bioavailability in drug formulations.
  • Imidazolidinone framework: The imidazolidin-2-one ring adds to the compound's stability and potential reactivity.

In summary, 1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methyl-imidazolidin-2-one is a compound that embodies the intersection of chemistry and pharmacology, inviting scholars and researchers to delve deeper into its mechanisms and applications. The potential for innovation in drug development remains vast, fueled by such complex structures that continue to inspire scientific inquiry.

Synonyms
Imiclopazine
Imiclopazina
Imiclopazine [INN]
Imiclopazinum
CHLORIMPIPHENINE
UNII-WGL8B3MDAS
WGL8B3MDAS
Imiclopazinum [INN-Latin]
Imiclopazina [INN-Spanish]
CHLORIMIPHENIN
IMICLOPAZINE [MI]
Imiclopazinum (INN-Latin)
Imiclopazina (INN-Spanish)
1-(2-(4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl)-3-methyl-2-imidazolidinone
1-(2-(4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl)-3-methyl-2-imidazolidinone
chlorimiphenine
1-[2-[4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl]-3-methyl-2-imidazolidinone
1-(2-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazinylethyl)-3-methyl-2-imidazolidinone
7224-08-0
1-[2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl]-3-methylimidazolidin-2-one
imiclopazin
Chorimpiphenine
SCHEMBL147414
Chlorimpiphenine dihydrochloride
CHEMBL2105043
DTXSID60864024
CHEBI:135784
2-Imidazolidinone, dihydrochloride
NSC113426
Q27292632
WLN: T C666 BN ISJ FG B3- AT6N DNTJ D2- AT5NVNTJ C1 &GH 2
1-(2-(3-(2-chlorophenothiazin- 10-yl)propyl)-1-piperazinylethyl)-3-methyl-2- imidazolidinone