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Raloxifene Hydrochloride

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Identification
Molecular formula
C28H28ClNO4
CAS number
82640-04-8
IUPAC name
1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine;hydrochloride
State
State

This compound is typically a solid at room temperature.

Melting point (Celsius)
260.00
Melting point (Kelvin)
533.15
Boiling point (Celsius)
832.70
Boiling point (Kelvin)
1 105.85
General information
Molecular weight
510.05g/mol
Molar mass
510.0540g/mol
Density
1.0067g/cm3
Appearence

Raloxifene hydrochloride is a white to pale-yellow solid. It is often available as a fine powder.

Comment on solubility

Solubility of 1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine; hydrochloride

The solubility of 1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine; hydrochloride is an intriguing aspect to consider, especially given its complex structure. This compound, being a hydrochloride salt, typically exhibits enhanced solubility in polar solvents. Here are some key points regarding its solubility:

  • Polar Solvents: The presence of the hydrochloride moiety suggests good solubility in water and other polar solvents, allowing for effective dissolution.
  • Solvent Dependency: Solubility may vary significantly with temperature and pH; warmer solvents might increase solubility further.
  • Potential Limitations: Despite its solubility in polar conditions, organic solvents might show less efficiency in dissolving this compound due to its hydrophilic characteristics.

In summary, while this compound is expected to have a favorable solubility profile in polar environments, the specific conditions of temperature and solvent choice must be carefully considered to optimize its solvation potential.

Interesting facts

Interesting Facts About 1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine;hydrochloride

This compound is a fascinating member of the class of substances known for their complex structures and intriguing chemical properties. Below are some notable aspects of this compound:

  • Pharmacological Potential: Due to its unique chemical structure, this compound may exhibit interesting pharmacological activities. Compounds with naphthalenic and pyrrolidine moieties are often explored in medicinal chemistry for their potential therapeutic effects.
  • Structure Activity Relationship: The presence of the methoxy group, combined with the two phenyl rings and the naphthalene portion, suggests enhanced lipophilicity and interactivity with biological targets, which can be crucial in determining the compound's efficacy as a drug.
  • Synthetic Accessibility: The multifaceted nature of its structure warrants discussions on synthetic methods. Scientists often strive to develop effective protocols for synthesizing intricate organic molecules while minimizing side reactions.
  • Chemical Behavior: As a hydrochloride salt, this compound may exhibit different solubility and stability compared to its free base form, influencing its bioavailability and performance in various applications.
  • Research Insights: The exploration of compounds like this one furthers our understanding of how specific molecular configurations can drastically alter biological activities—a vital aspect in drug design.

Overall, 1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine;hydrochloride serves as a prime example of the complexity found in organic compounds and opens the door to numerous research possibilities in both synthetic and medicinal chemistry.

Synonyms
NAFOXIDINE HYDROCHLORIDE
1847-63-8
Nafoxidine HCl
U-11100A
U 11100A
NSC-70735
CCRIS 3620
U 11100
UNII-SU8WBD61G1
Nafoxidine hydrochloride [USAN:INN]
SU8WBD61G1
11100A
NSC 70735
1-(2-(p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
Nafoxidine hydrochloride (USAN)
DTXSID30171651
NSC70735
U-11100
1-(2-(p-(6-Methoxy-2-phenyl-3,4-dihydro-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
NAFOXIDINE HYDROCHLORIDE [USAN]
Pyrrolidine 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-, hydrochloride
1-[2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride
1-[2-[p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]ethyl]pyrrolidine hydrochloride
Pyrrolidine, 1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)-, hydrochloride
1-(2-(4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)pyrrolidine Hydrochloride
Hydrochloride, Nafoxidine
DTXCID6094142
U-11,000A
439-520-1
606-036-9
1847-63-8 (HCl)
1-(2-(4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidine hydrochloride
1-[2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]-pyrrolidine hydrochloride,
1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine;hydrochloride
Pyrrolidine,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]ethyl)-, hydrochloride
Pyrrolidine,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]ethyl]-, hydrochloride
1-{2-[4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride
CP-5600
Nafoxidine (hydrochloride)
NAFOXIDINEHYDROCHLORIDE
SCHEMBL115778
CHEMBL2106733
BCP07493
AKOS024464148
AKOS025243227
HY-W040046
AC-29994
LS-15259
Pyrrolidine 1-[2-[4-(3, hydrochloride
Nafoxidine hydrochloride, >=98% (HPLC)
NS00134112
D05106
Q27289409
1-[2-[p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]ethyl]pyrrolidinehydrochloride
Pyrrolidine,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]-, hydrochloride
{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride
1-[2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride;
1-[2-[4-(6-methoxy-2-phenyl-3,4 dihydronaphthalen-1-yl) phenoxy]ethyl]pyrrolidine hydrochloride
1-[2-[4-(6-methoxy-2-phenyl-3,4 dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine hydrochloride
1-[2-[4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen 1 yl)phenoxy]ethyl]pyrrolidine hydrochloride
1-[2-[4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen 1yl)phenoxy]ethyl]pyrrolidine hydrochloride
1-{2-[4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1yl)phenoxy]ethyl}pyrrolidine hydrochloride
Pyrrolidine,1-[2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]-,hydrochloride (1:1)