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Clorazepate

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Identification
Molecular formula
C19H22ClNO2
CAS number
14611-52-0
IUPAC name
1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, the compound is a solid, typically found in powdered form.

Melting point (Celsius)
132.00
Melting point (Kelvin)
405.20
Boiling point (Celsius)
263.50
Boiling point (Kelvin)
536.70
General information
Molecular weight
305.80g/mol
Molar mass
305.8020g/mol
Density
1.2000g/cm3
Appearence

This compound typically appears as a white solid. It is often found as a crystalline powder, characterized by its fine texture.

Comment on solubility

Solubility of 1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

The solubility of 1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline can be quite intriguing, as it involves various factors that determine its behavior in different solvents.

Generally, the solubility of a compound is influenced by:

  • Molecular Structure: The presence of various functional groups, such as methoxy and ethyl, can impact how well the compound interacts with solvents.
  • Polarity: The balance between polar and non-polar characteristics plays a crucial role in solubility. The methoxy groups tend to increase polarity, which may enhance solubility in polar solvents.
  • Temperature: Higher temperatures can often increase solubility as more kinetic energy facilitates solute-solvent interactions.
  • pH Levels: If the compound exhibits protonation or deprotonation, changes in pH can significantly affect solubility.

In laboratory settings, the compound may demonstrate variable solubility profiles:

  • High Solubility: In polar solvents like alcohols or dimethyl sulfoxide (DMSO).
  • Low Solubility: In non-polar solvents such as hexane or toluene.

As a general observation, “like dissolves like.” Thus, the interactions of 1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline will depend heavily on the solvent’s own characteristics. Overall, it is important to consider these aspects when experimenting with solubility to obtain optimal results.

Interesting facts

Interesting Facts about 1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

This intriguing compound belongs to the family of isoquinoline derivatives, a class of organic compounds known for their diverse biological activities. Isoquinolines are often investigated for their potential pharmacological properties, making them a significant focus in medicinal chemistry.

Key Highlights:

  • Pharmacological Potential: Many isoquinoline derivatives have shown potential in treating various diseases, including neurodegenerative conditions, and possess antimicrobial and anticancer activities.
  • Chlorophenyl Substitution: The presence of a 4-chlorophenyl group can enhance the compound's biological activity, often by influencing its lipophilicity and ability to interact with biological targets.
  • Dimethoxy Groups: The two methoxy (-OCH3) groups in this structure may play a role in modulating the compound's activity, as methoxy groups are known to affect the electronic properties and sterics of molecules.

This compound's structure also hints at interesting synthetic pathways. The isoquinoline framework could be synthesized through various methods, including traditional cyclization reactions or more advanced techniques such as palladium-catalyzed coupling reactions.

As research continues, understanding how such compounds interact at the molecular level can lead to the development of novel therapies. Investigators often ask: What secrets may lie within these intricate isoquinoline-based structures?

In conclusion, 1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline serves as a fascinating compound, reflecting the complexities and possibilities within medicinal chemistry and the broader field of organic synthesis.

Synonyms
Metofoline
Methopholine
Metopholine
Versidyne
2154-02-1
Mesofolin
ARC I-K-1
NIH 7672
Ro 4-1778/1
Methopholine [USAN]
Metofolina
Metofoline [INN]
Metofoline, (-)-
Methopholine, (-)-
NSC-169889
ARC-I-K-1
UNII-T8093YH1A3
72L4ZT2W1P
ARC 1-K-1
T8093YH1A3
NIH-7672
1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
NSC169889
Methopholine (USAN)
Ro 4-1778
Ro 41778/1
NIH 7672;ARC-1-K-1;ARC I-K-1
1-(p-Chlorophenethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline
Isoquinoline, 1-(2-(4-chlorophenyl)ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-
ISOQUINOLINE, 1-(p-CHLOROPHENETHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-
Metofoline, (+)-
Isoquinoline, 1-(2-(4-chlorophenyl)ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (-)-
Methopholine, (+)-
180003-15-0
Metofolinum [INN-Latin]
Metofolina [INN-Spanish]
Metofolinum
958H0E3A4Y
NSC 169889
METOFOLINE [MI]
UNII-72L4ZT2W1P
Oprea1_250682
SCHEMBL26169
UNII-958H0E3A4Y
CHEMBL2106915
NIOSH/NX4948000
DTXSID90862851
CHEBI:135462
YBCPYHQFUMNOJG-UHFFFAOYSA-N
14415-95-3
Isoquinoline, 1-(2-(4-chlorophenyl)ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (+)-
1-(p-Chlorophenethyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
1-(p-Chlorophenethyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
NS00126824
NX49480000
RO-4-1778/1
D04986
WLN: T66 CNT&J B2R DG& C1 HO1 IO1
Q6824210
1-(p-Chlorophenethyl)-6,2,3,4-tetrahydroisoquinoline
Isoquinoline,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-
1-(p-Chlorophenethyl)-2-methyl-6,2,3,4-tetrahydroisoquinoline
1-(p-Chlorophenethyl)-1,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline
(+-)-1,2,3,4-Tetrahydro-1-(4-chlorophenethyl)-6,7-dimethoxy-2-methylisoquinoline
1-(2-(4-Chlorophenyl)ethyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
1-(p-Chlorophenethyl)-1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methylisoquinoline
1-(p-Chlorophenethyl)-2-methyl-6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinoline
1-(p-Chlorophenethyl)-6, 7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
Isoquinoline, {1-[2-(4-chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6,} 7-dimethoxy-2-methyl-
Isoquinoline, 1,2,3,4-tetrahydro-1-(4-chlorophenethyl)-6,7-dimethoxy-2-methyl-, (+-)-
Isoquinoline, 1-(p-chlorophenethyl)-1,2,3, 4-tetrahydro-6,7-dimethoxy-2-methyl-