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Clocapramine hydrochloride

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Identification
Molecular formula
C20H25Cl2NO2S
CAS number
86640-81-3
IUPAC name
1-[2-(4-chlorophenyl)sulfanylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
State
State

At room temperature, Clocapramine hydrochloride is typically in the solid state.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
234.00
Boiling point (Kelvin)
507.15
General information
Molecular weight
436.96g/mol
Molar mass
436.9600g/mol
Density
1.3200g/cm3
Appearence

Clocapramine hydrochloride appears as a white crystalline powder. It is often used in clinical applications and should be handled under appropriate laboratory conditions.

Comment on solubility

Solubility of 1-[2-(4-chlorophenyl)sulfanylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride

The solubility of 1-[2-(4-chlorophenyl)sulfanylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride can be influenced by various factors, making it an intriguing compound to analyze. Here are some notable points regarding its solubility:

  • Polarity: The presence of the ionic chloride component indicates that the compound is likely to be soluble in polar solvents, such as water. The positive charge on the tetrahydroisoquinoline structure suggests it may interact favorably with polar molecules.
  • Functional Groups: The existence of methoxy (-OCH3) groups enhances solvation, potentially increasing solubility in organic solvents.
  • Influence of the Sulfanyl Group: The sulfanylethyl bridge may contribute hydrophobic characteristics, which could limit solubility in highly polar environments but allow for better solubility in less polar organic solvents.
  • Temperature: Generally, solubility can increase with temperature. Therefore, considering the effect of temperature on the solubility of this compound may provide additional insights.

In conclusion, the solubility of this compound is multifaceted, depending on the balance between its polar and nonpolar characteristics. It is essential to consider the specific solvent and conditions when evaluating its solubility.

Interesting facts

Interesting Facts about 1-[2-(4-chlorophenyl)sulfanylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

This compound, known for its complex structure and engaging properties, falls within the realm of organic chemistry, showcasing the fascinating diversity of tetrahydroisoquinoline derivatives. Here are some noteworthy aspects:

  • Synthesis and Utilization: Tetrahydroisoquinolines are often synthesized using approaches such as the Pictet–Spengler reaction, which makes this compound a subject of interest for researchers in synthetic organic chemistry.
  • Pharmacological Potential: Compounds like this are frequently explored for their potential medicinal properties, particularly as they may exhibit neuroprotective, antidepressant, or even antitumor activities. Their ability to modulate neurotransmitter systems is an area of considerable interest.
  • Structural Complexity: The presence of both a sulfonyl group and multiple methoxy groups indicates this compound's potential for varied interactions within biological systems. The chlorine substituent on the phenyl ring may enhance its lipophilicity, influencing its permeability and biological activity.
  • Research Applications: This compound's properties render it a promising candidate for the study of new therapeutic agents, particularly in neuropharmacology and medicinal chemistry. It paves the way for the development of novel medications targeting various mental health disorders.

In the world of chemical research, understanding the behavior of such compounds is essential. They not only provide insights into fundamental chemical processes but also open doors for advancements in drug discovery.

As one researcher noted, "The intricacies of molecular interactions in compounds like this inspire a deeper understanding of how we can manipulate them toward therapeutic goals." This emphasizes the exciting potential that lies within each chemical structure.

Synonyms
22309-29-1
UNII-E2W214J53A
E2W214J53A
1-(2-((p-Chlorophenyl)thio)ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinoline HCl
1-(2-((4-Chlorophenyl)thio)ethyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
Isoquinoline, 1-(2-((p-chlorophenyl)thio)ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, hydrochloride
1-[2-(4-chlorophenyl)sulfanylethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium chloride
1-(2-(4-CHLOROPHENYL)SULFANYLETHYL)-6,7-DIMETHOXY-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-2-IUM CHLORIDE
1-(2-((P-CHLOROPHENYL)THIO)ETHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-
ISOQUINOLINE, 1-(2-((4-CHLOROPHENYL)THIO)ETHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-, HYDROCHLORIDE (1:1)
RefChem:196899
Q27276795