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Meclizine

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Identification
Molecular formula
C25H27ClN2
CAS number
569-65-3
IUPAC name
1-[2-(6-methyl-2-pyridyl)ethyl]-4-phenyl-piperazine
State
State

Meclizine is typically in the form of solid tablets or powders at room temperature.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
302.00
Boiling point (Kelvin)
575.15
General information
Molecular weight
390.96g/mol
Molar mass
390.9920g/mol
Density
1.1508g/cm3
Appearence

Meclizine is typically found in the form of white to slightly yellow crystalline powder. It may also appear as tablets available in various colors depending on the formulation and manufacturer. The powder is odorless and has a bitter taste.

Comment on solubility

Solubility of 1-[2-(6-methyl-2-pyridyl)ethyl]-4-phenyl-piperazine

The solubility of 1-[2-(6-methyl-2-pyridyl)ethyl]-4-phenyl-piperazine can be quite intriguing due to its unique chemical structure. As a piperazine derivative, this compound exhibits certain solubility characteristics influenced by both its hydrophobic and hydrophilic properties. Generally, solubility can be discussed in terms of solvent interactions:

  • Polar Solvents: Compounds like this one, which contain nitrogen atoms, often show increased solubility in polar solvents, such as water or methanol, due to hydrogen bonding.
  • Non-Polar Solvents: The hydrophobic phenyl and pyridyl groups tend to enhance solubility in non-polar solvents, allowing for better dissolution in organic solvents like chloroform or ethanol.
  • Temperature Dependence: The solubility may also vary significantly with temperature; typically, an increase in temperature increases solubility for many organic compounds.

In practical applications, understanding the solubility of this compound is essential, as it affects its bioavailability and interaction with other chemical species. As such, one might find it beneficial to consider various solvent environments in experimental design when working with this compound.

In conclusion, the solubility of 1-[2-(6-methyl-2-pyridyl)ethyl]-4-phenyl-piperazine is a nuanced topic influenced by several factors, including:

  1. The presence of functional groups that can interact with solvents.
  2. The overall molecular architecture, which determines compatibility with different solvent types.
  3. Environmental conditions such as temperature and pressure.

Thus, careful consideration of these factors will aid in predicting and enhancing the solubility of this compound in various contexts.

Interesting facts

Interesting Facts about 1-[2-(6-methyl-2-pyridyl)ethyl]-4-phenyl-piperazine

1-[2-(6-methyl-2-pyridyl)ethyl]-4-phenyl-piperazine is a chemical compound that belongs to the family of piperazines, which are bicyclic organic compounds. Here are some intriguing aspects to consider:

  • Pharmacological Potential: This compound is part of a class of molecules that have been studied for their synthetic utility in medicinal chemistry. Research indicates its potential as an antidepressant and anxiolytic agent, making it a subject of interest for psychopharmacology.
  • Chemical Structure: The presence of a pyridine moiety lends unique electronic properties to the molecule, which can influence its interactions with biological targets.
  • Receptor Interaction: Research has suggested that it may exhibit activity at serotonin receptors, particularly the 5-HT (serotonin) receptors, which are critical for mood regulation.
  • Analog Development: The versatility in the structure allows chemists to synthesize various analogs that can be fine-tuned for enhanced efficacy or reduced side effects, showcasing the importance of structure-activity relationships in drug design.
  • Combinatorial Chemistry: The exploration of this compound is often conducted in the realm of combinatorial chemistry, allowing scientists to quickly generate and test numerous derivatives to find optimal candidates for therapeutic use.

In summary, 1-[2-(6-methyl-2-pyridyl)ethyl]-4-phenyl-piperazine serves not only as a fascinating compound in terms of its potential applications in medicine but also as a prime example of how intricate chemical design leads to significant advances in drug development. The ongoing research around it emphasizes the ever-evolving landscape of pharmaceutical science and the vital role of piperazine derivatives in the search for innovative therapeutic agents.

Synonyms
1-[2-(6-methylpyridin-2-yl)ethyl]-4-phenylpiperazine
23256-10-2
J119BL6Z4Z
DTXSID00274926
1-(2-(6-METHYL-2-PYRIDINYL)ETHYL)-4-PHENYLPIPERAZINE
1-(2-(6-METHYL-2-PYRIDYL)ETHYL)-4-PHENYLPIPERAZINE
PIPERAZINE, 1-(2-(6-METHYL-2-PYRIDINYL)ETHYL)-4-PHENYL-
PIPERAZINE, 1-(2-(6-METHYL-2-PYRIDYL)ETHYL)-4-PHENYL-