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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine
State
State

At room temperature, diphenhydramine is typically in a solid state, appearing as a fine white powder.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
327.40
Boiling point (Kelvin)
600.55
General information
Molecular weight
255.36g/mol
Molar mass
255.3640g/mol
Density
1.0060g/cm3
Appearence

Diphenhydramine is typically seen as a white, crystalline powder. It does not have a characteristic smell and can be easily dissolved in alcohol, but is less soluble in water at room temperature.

Comment on solubility

Solubility of 1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine

The solubility of 1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine (C17H21NO) is influenced by its structural characteristics. This compound features a piperazine ring, which contributes to its solubility properties in various solvents.

Key Points on Solubility:

  • Polarity: The presence of both hydroxyethyl and phenyl groups indicates a balance between hydrophilic and hydrophobic characteristics, affecting its solubility in water and organic solvents.
  • Solvents: Generally, compounds like this are more soluble in organic solvents, such as ethanol and methanol, due to their non-polar aromatic rings.
  • Temperature Dependency: Solubility can increase with temperature; thus testing at various temperatures may provide a more accurate profile.
  • pH Influence: The pH of the solution may also play a critical role, especially if any functional groups can be protonated or deprotonated.

In summary, whilst it is expected that C17H21NO will demonstrate limited solubility in water, it is likely to be readily soluble in more polar organic solvents, making it suitable for various applications dependent on its solubility profile.

Interesting facts

Exploring 1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine

1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine is a fascinating compound that falls within the realm of piperazine derivatives. Here are some intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound has garnered attention for its potential applications in pharmacology. Its structure suggests possible activity as a pharmacological agent, which prompts interest in its study for potential therapeutic uses.
  • Structural Complexity: The unique combination of a piperazine ring with benzhydryloxyethyl and phenylpropyl groups contributes to the compound's interesting stereochemistry and steric effects, potentially influencing its biological activity.
  • Research Potential: Being a derivative of piperazine, this compound can be a starting point for the synthesis of novel agents, making it an attractive target for medicinal chemistry research.
  • Mechanism of Action: Due to its structural similarities with known psychoactive agents, researchers are keen on understanding its mechanism of action within the central nervous system. This could lead to breakthroughs in treating various neuropsychiatric disorders.

As stated in the words of a well-known chemist, "Innovation in chemistry is at the forefront of solving human health challenges." With compounds like 1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine, the opportunities for innovation are abundant. As we continue to explore this compound, it will be exciting to see how it may contribute to advancements in medicine and therapeutic development.

Synonyms
76778-22-8
Gbr 12935
GBR-12935
1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine
GBR12935
1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine
1-(2-(benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine
1-(2 (Diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine
GBR-12935 free base
CHEMBL26320
9J9974WIBA
CHEBI:64093
76778-22-8 (free base)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine
1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine
Piperazine, 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)-
Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-
UNII-9J9974WIBA
[3H]GBR12935
[3H]-GBR12935
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
Tocris-0514
1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine maleate
Lopac-G-9659
Biomol-NT_000056
Lopac0_000560
MLS006012605
SCHEMBL726349
BPBio1_001315
GTPL4638
GTPL4639
1-hydrocinnamyl-4-(2-(diphenylmethoxy)ethyl)piperazine
DTXSID2043743
BDBM22167
BCP02704
HY-12242A
AKOS028110061
CCG-204650
CS-3131
FG65031
SDCCGSBI-0050543.P002
NCGC00015484-01
NCGC00015484-02
NCGC00015484-03
NCGC00015484-04
NCGC00015484-05
NCGC00015484-06
NCGC00024628-01
NCGC00024628-02
NCGC00024628-03
DA-73669
SMR004704148
J227.604F
D87612
Q5512952
BRD-K50135270-001-01-9
BRD-K50135270-300-01-5
BRD-K50135270-300-02-3