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1-(2-Benzoylpyrrol-1-yl)-4-morpholinobutan-2-one

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Identification
Molecular formula
C19H22N2O3
CAS number
91485-24-8
IUPAC name
1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one
State
State

At room temperature, 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one is typically found as a solid.

Melting point (Celsius)
99.50
Melting point (Kelvin)
372.70
Boiling point (Celsius)
453.60
Boiling point (Kelvin)
726.80
General information
Molecular weight
342.39g/mol
Molar mass
342.3940g/mol
Density
1.2548g/cm3
Appearence

The compound 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one typically appears as an off-white to pale yellow crystalline powder. Its color might vary slightly based on the method of synthesis and the purity of the compound. The crystals are usually fine and can be quite fragile.

Comment on solubility

Solubility of 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one

The solubility of 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one is influenced by several factors, primarily its structural characteristics and the nature of the solvent. Understanding these factors can provide insights into its behavior in various environments.

Factors Affecting Solubility

  • Polarity: The compound contains both polar and non-polar functional groups, which contributes to its solubility in a range of solvents.
  • Hydrogen Bonding: The presence of the morpholino group can engage in hydrogen bonding, making the compound more soluble in polar solvents like water or alcohols.
  • Temperature: Increasing temperature generally enhances solubility for solids, possibly improving the solubility of this compound as well.
  • pH Levels: Changes in pH can impact the ionization of the morpholino group, thereby affecting solubility in aqueous environments.

Based on these characteristics, it can be anticipated that 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one would demonstrate differing solubility profiles in polar versus non-polar solvents. However, it's important to note that empirical solubility data should be consulted for precise applications.

Potential Solubility Insights

In practice, the solubility of this compound could be summarized as follows:

  • Likely soluble in polar solvents due to its hydrogen bonding potential.
  • Possibly insoluble or only slightly soluble in non-polar solvents because of the presence of polar functional groups.

In conclusion, understanding the solubility of 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one is crucial for its application in chemical formulations and demonstrates the importance of comprehensive solvent interactions.

Interesting facts

Interesting Facts about 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one

This compound, known for its complex structure and unique properties, belongs to the family of pyrrol-derived compounds, which are often investigated for their diverse biological activities. Here are some engaging facts that highlight its significance:

  • Pharmaceutical Potential: Compounds containing the pyrrol moiety have been explored for their potential as antidepressants, antimicrobials, and antitumor agents. Research indicates that 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one may possess interesting medicinal properties.
  • Structure-Activity Relationship (SAR): The unique combination of a benzoyl group and a morpholino group in its structure leads to notable variations in activity. Understanding the SAR is crucial in drug development as it helps predict how structural modifications can enhance desired effects.
  • Research Applications: This compound can serve as a valuable tool for researchers in various fields, including medicinal chemistry and pharmacology, where understanding its interactions within biological systems can lead to the discovery of new therapeutic agents.
  • Chemical Reactions: The presence of multiple functional groups allows for various synthetic pathways, making it a versatile building block in organic synthesis. Researchers often explore its reactivity to develop new derivatives with improved pharmacological profiles.
  • Historical Context: The study of pyrrol derivatives dates back to the early 20th century, but their potential in modern medicine is continually expanding, reflecting the ongoing interest in harnessing natural and synthetic tools for healthcare innovation.

In conclusion, 1-(2-benzoylpyrrol-1-yl)-4-morpholino-butan-2-one stands out not just for its intriguing chemical structure, but also for its potential to pave the way for future breakthroughs in pharmaceutical research.