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Flunarizine

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Identification
Molecular formula
C26H26F2N2O
CAS number
52468-60-7
IUPAC name
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
State
State

Flunarizine is typically a solid at room temperature, taking the form of a crystalline powder.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.15
Boiling point (Celsius)
536.30
Boiling point (Kelvin)
809.45
General information
Molecular weight
404.50g/mol
Molar mass
404.5180g/mol
Density
1.1525g/cm3
Appearence

Flunarizine is a white to off-white crystalline powder. It is practically insoluble in water but soluble in most organic solvents.

Comment on solubility

Solubility of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine

The solubility of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, with the chemical formula C26H26F2N2O, can be quite complex and is influenced by various factors. Here are some important points to consider:

  • Polarity: The presence of both hydrophobic (aromatic rings) and hydrophilic (methoxy and amine groups) components affects solubility in polar and non-polar solvents.
  • Solvent Interaction: This compound is likely to show better solubility in organic solvents due to its aromatic nature and the presence of fluorine substituents, which enhance interactions.
  • Temperature Dependency: Solubility may increase with temperature, a common characteristic of many organic compounds.

In summary, while definitive solubility data may require empirical testing, the theoretical aspects indicate that:

  • It may have moderate to high solubility in organic solvents such as ethanol, methanol, and dichloromethane.
  • In water, the solubility could be limited due to its predominantly hydrophobic structure.

Thus, understanding the solubility of this compound is crucial for its applications in chemical synthesis and formulation.

Interesting facts

Interesting Facts about 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine

This intriguing compound is notable for its complex structure and potential applications in medicinal chemistry. Here are some insights:

  • Pharmaceutical Potential: The piperazine core, a common motif in various pharmacologically active compounds, plays a vital role in influencing the bioactivity of the molecule. This particular compound could exhibit properties relevant to the development of new antidepressants, anxiolytics, or antipsychotics.
  • Fluorine's Role: The presence of 4-fluorophenyl groups can enhance the lipophilicity of the compound, possibly improving its interaction with lipid membranes and cellular targets, which is crucial for drug delivery and efficacy.
  • Structure-Activity Relationship: The unique combination of ethyl and phenyl substitution patterns may allow for fine-tuning of the compound's activity. Researchers often explore these relationships to optimize therapeutic effects while minimizing side effects.
  • Research Interest: Due to its structural uniqueness, this compound could be a subject of interest in studies focused on receptor binding and pharmacokinetics. It provides a fascinating opportunity to investigate how variations in chemical structure impact biological function.
  • Analytical Challenges: The compound's complexity might pose challenges for analytical techniques. Understanding its behavior in various conditions is essential for effective characterization and development processes.

Overall, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine stands out in the field of chemistry not just for its molecular complexity, but also for its potential to open new avenues in drug discovery and therapeutic applications.

Synonyms
Vanoxerine
67469-69-6
Gbr 12909
Vanoxerina
Vanoxerinum
Vanoxerine [INN]
Vanoxeamine
GBR-12909
GBR12909
Vanoxerinum [INN-Latin]
Vanoxerina [INN-Spanish]
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine
UNII-90X28IKH43
CHEBI:64089
90X28IKH43
1-(2-(Bis(p-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine
CHEMBL281594
DTXSID8045143
67469-69-9 (free base)
1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine
GBR 12909;I893
I 893
I-893
Vanoxerinum (INN-Latin)
Vanoxerina (INN-Spanish)
CAS-67469-78-7
1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine
Tocris-0421
SpecPlus_000900
Lopac-D-052
Prestwick0_000386
Prestwick1_000386
Prestwick2_000386
Prestwick3_000386
Biomol-NT_000010
Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-
A1D5S
Lopac0_000446
BSPBio_000571
DivK1c_006996
SCHEMBL246574
SPBio_002492
BPBio1_000629
BPBio1_001141
GTPL9983
DTXCID6025143
BDBM22165
KBio1_001940
NAUWTFJOPJWYOT-UHFFFAOYSA-N
BCPP000022
HMS3742I03
BCP21322
1-(2 (bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine
HY-13217A
AKOS003588978
CCG-204538
DB03701
SB16842
SDCCGSBI-0050431.P003
1-(2 (bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
NCGC00015300-01
NCGC00015300-02
NCGC00015300-03
NCGC00015300-04
NCGC00015300-07
NCGC00015300-08
NCGC00015300-17
NCGC00024581-01
NCGC00024581-02
NCGC00024581-03
NCI60_038175
AB00053750
NS00071657
Q2510480
BRD-K32501161-001-01-7
BRD-K32501161-300-03-9
BRD-K32501161-300-04-7
BRD-K32501161-300-06-2
GBR-12909; GBR12909; GBR 12909; I-893; I 893; I893
110872-73-6