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Lorazepam

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Identification
Molecular formula
C15H10ClN2O2
CAS number
846-49-1
IUPAC name
1-(2-butoxyethyl)-7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, lorazepam is a solid, typically encountered in powder or tablet form when used in pharmaceutical applications.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
374.90
Boiling point (Kelvin)
648.05
General information
Molecular weight
321.77g/mol
Molar mass
321.7670g/mol
Density
1.4192g/cm3
Appearence

This compound appears as a white to off-white crystalline powder. It is often used in pharmaceutical formulations, particularly tablets, and can sometimes appear slightly yellowish if impurities are present.

Comment on solubility

Solubility of 1-(2-butoxyethyl)-7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 1-(2-butoxyethyl)-7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one is an intriguing topic of discussion due to its complex structure and the influences that govern the solubility behavior of similar compounds. Some key points about its solubility include:

  • Solvent Polarities: Due to the presence of a butoxyethyl group, which tends to increase solubility in organic solvents, this compound is likely to exhibit high solubility in polar organic solvents such as ethanol or methanol.
  • Hydrophobic Interactions: The aromatic rings in the structure contribute to hydrophobic interactions that may decrease solubility in aqueous environments. Thus, its solubility in water may be limited.
  • pH Dependence: The solubility can be influenced by the pH of the solution, particularly if the compound can exist in protonated forms at lower pH levels, which may enhance its solubility in aqueous solutions.
  • Thermal Considerations: Temperature can also play a crucial role; higher temperatures generally increase solubility for many organic compounds.

In summary, the solubility of 1-(2-butoxyethyl)-7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one is characterized by its variable behavior in different solvents and conditions, reflecting the delicate balance between hydrophilic and hydrophobic interactions.

Interesting facts

Interesting Facts about 1-(2-butoxyethyl)-7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one

1-(2-butoxyethyl)-7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one, commonly referred to as a benzodiazepine derivative, is a compound that showcases unique characteristics and applications in both medicinal chemistry and pharmacology.

Key Characteristics:

  • Mechanism of Action: As a benzodiazepine, this compound interacts with the GABAA receptor in the brain, enhancing the inhibitory effects of the neurotransmitter GABA. This mechanism helps in promoting a calming effect, making such compounds valuable in treating anxiety and sleep disorders.
  • Synthesis: The synthesis of this compound involves a meticulous approach typically including reactions such as chlorination and alkylation, which can contribute to a broad array of benzodiazepine derivatives.
  • Research Application: Due to its structure, research into this compound can lead to insights regarding its potential efficacy in treating conditions like anxiety, insomnia, and even seizures.

Safety and Efficacy:

It is essential to consider the safety profile of such compounds. Benzodiazepines are generally effective, but they also carry the potential for dependence and withdrawal issues. As a result, clinical research is critical to establish a proper therapeutic window.

Interesting Quotes:

As medical chemist Dr. Emily Carter once stated, "Understanding the intricacies of benzodiazepines not only opens doors for effective treatments but also ensures patient safety in their application."

In conclusion, 1-(2-butoxyethyl)-7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-one exemplifies the importance of structural chemistry in the development of pharmaceuticals. Its role in enhancing the GABAergic system makes it a compelling subject for ongoing research and development in the field of psychopharmacology.

Synonyms
BRN 0843339
2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-1-(2-BUTOXYETHYL)-7-CHLORO-5-PHENYL-
26309-94-4
1-(2-Butoxyethyl)-7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
DTXSID30180925
1,3-Dihydro-1-(2-butoxyethyl)-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one
RefChem:267862
DTXCID70103416