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Chlorpromazine

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Identification
Molecular formula
C17H19ClN2OS
CAS number
50-53-3
IUPAC name
1-(2-chloro-5-oxo-phenothiazin-10-yl)-3-(dimethylamino)propan-1-one
State
State
The compound is typically a solid at room temperature, available as a finely divided powder.
Melting point (Celsius)
196.50
Melting point (Kelvin)
469.65
Boiling point (Celsius)
400.15
Boiling point (Kelvin)
673.30
General information
Molecular weight
355.32g/mol
Molar mass
355.3200g/mol
Density
1.4530g/cm3
Appearence

Chlorpromazine appears as a white or slightly creamy granular powder. It can sometimes have a yellowish tint depending on the crystalline form. It is typically odorless or may have a faint amine-like odor.

Comment on solubility

Solubility of 1-(2-chloro-5-oxo-phenothiazin-10-yl)-3-(dimethylamino)propan-1-one

The solubility of 1-(2-chloro-5-oxo-phenothiazin-10-yl)-3-(dimethylamino)propan-1-one is a complex property influenced by its molecular structure and interactions with solvents. Understanding its solubility behavior is crucial for applications in pharmaceuticals and related fields.

Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups, such as the dimethylamino group, typically enhances solubility in polar solvents like water, whereas the phenothiazine moiety may exhibit hydrophobic characteristics, affecting overall solubility.
  • Temperature: Increased temperature can significantly impact solubility, often promoting dissolution by increasing molecular motion.
  • pH Levels: The solubility of this compound may also vary with pH due to potential protonation of the dimethylamino group, altering its solubility profile.

As a general observation, compounds related to phenothiazine derivatives often show varying degrees of solubility in organic solvents, but can be less soluble in aqueous solutions. These characteristics must be carefully evaluated during experimentation and formulation.

Key Points:

  1. Examine solvent interactions, especially in mixed solvent systems.
  2. Consider the role of temperature and pH in enhancing solubility.
  3. Test different organic solvents to determine the most suitable medium.

In conclusion, understanding the solubility of 1-(2-chloro-5-oxo-phenothiazin-10-yl)-3-(dimethylamino)propan-1-one is vital for its successful application in various scientific fields. As such, it's essential to conduct thorough solubility assessments to maximize its utility.

Interesting facts

Interesting Facts About 1-(2-chloro-5-oxo-phenothiazin-10-yl)-3-(dimethylamino)propan-1-one

This fascinating compound belongs to a class of chemicals known for their diverse applications in pharmaceuticals and organic synthesis. The structure of 1-(2-chloro-5-oxo-phenothiazin-10-yl)-3-(dimethylamino)propan-1-one includes multiple functional groups that enhance its reactivity and versatility.

Chemical Properties

  • Phenothiazine Derivative: This compound is a derivative of phenothiazine, a compound historically utilized in the development of antipsychotic medications, showcasing its potential in medicinal chemistry.
  • Chlorine Substitution: The presence of chlorine atoms can significantly influence the compound's biological activity and properties, making it an interesting subject for research and development.
  • Dimethylamino Groups: The dimethylamino group introduces basic character to the molecule, potentially affecting its solubility and interaction with biological targets.

Applications and Significance

The multifaceted structure of this compound makes it a candidate for various applications, particularly in the fields of drug discovery and material science. Some notable aspects include:

  • Potential therapeutic uses in mental health treatments due to its phenothiazine core.
  • Research into its ability to function as a biomarker or tool in biochemical assays.
  • Exploration as a starting material in the synthesis of novel compounds.

Scientists often remark that compounds with rich structures like this one pave the way for innovation in chemical research. As chemists continue to explore their properties and reactions, the potential for new discoveries remains abundant.

Conclusion

1-(2-chloro-5-oxo-phenothiazin-10-yl)-3-(dimethylamino)propan-1-one serves as a prime example of how chemical complexity can lead to diverse applications. Its implications in pharmacology and beyond underline the importance of thorough investigation in the realm of chemical compounds.

Synonyms
Acylphenothiazine
13420-96-7
2-Chloro-10-(beta-dimethylaminopropionyl)phenothiazine 5-oxide
Skf 17,910-A
10H-Phenothiazine, 2-chloro-10-(3-(dimethylamino)-1-oxopropyl)-, 5-oxide
SKF 17910-A
SK&F 17910-A
1-(2-chloro-5-oxophenothiazin-10-yl)-3-(dimethylamino)propan-1-one
SK&F 17,910-A
DTXSID40928517
2-Chloro-10-[3-(dimethylamino)propanoyl]-5lambda~4~-phenothiazin-5(10H)-one