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Nifurimide

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Identification
Molecular formula
C9H9ClN4O3
CAS number
17692-00-1
IUPAC name
1-(2-chloroethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one
State
State

At room temperature, Nifurimide is usually a solid. This solid-state is evident in its dry, powdered form, which is typically stable under normal room conditions and indicates that it does not readily sublimate or melt without applied heat.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
352.00
Boiling point (Kelvin)
625.15
General information
Molecular weight
255.64g/mol
Molar mass
255.6340g/mol
Density
1.5600g/cm3
Appearence

Nifurimide is usually presented as a yellow crystalline powder. Its distinct color can be attributed to the nitro and furyl groups in its structure. The powder is typically fine and absorbs moisture from the air.

Comment on solubility

Solubility of 1-(2-chloroethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one

The solubility of 1-(2-chloroethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one can be influenced by several factors, which are pivotal in understanding its potential applications.

Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups in the compound affects its ability to dissolve in polar solvents, which can improve solubility.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents such as water can enhance solubility significantly.
  • Temperature: As temperature increases, many compounds exhibit higher solubility; thus, it's essential to consider the thermal conditions when assessing solubility.

In general, due to the complex structure of this compound, it is likely to have variable solubility:

  • It may exhibit moderate solubility in organic solvents like ethanol and DMSO, while potentially being less soluble in water.
  • Understanding the solubility profile is crucial for applications such as drug formulation, where solubility determines bioavailability.

As a general rule, if a compound possesses both hydrophilic and hydrophobic regions, it can lead to amphiphilic properties, which may enhance solubility in mixed solvent systems.

Ultimately, careful evaluation of the solubility properties of 1-(2-chloroethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one will be essential for its practical applications in various fields.

Interesting facts

Interesting Facts about 1-(2-chloroethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one

This compound, known for its complex structure and diverse applications, represents an intriguing area of study in both organic chemistry and medicinal chemistry. Here are some captivating aspects to consider:

  • Pharmaceutical Relevance: The presence of the imidazolidin-2-one moiety in this compound may suggest potential pharmaceutical properties, often associated with anti-inflammatory and antimicrobial activities.
  • Nitro Group Contribution: The 5-nitro-2-furyl component can enhance biological activity, making compounds with this functional group interesting candidates for drug development due to their ability to interact with biological targets.
  • Mechanism Exploration: Researchers are often interested in studying the mechanisms through which compounds like this can exhibit their chemical reactivity. Understanding these pathways can lead to innovative therapeutic strategies.
  • Structural Diversity: The combination of furan and imidazolidinone moieties illustrates the *architectural diversity* possible in organic compounds, which is essential in developing new materials with bespoke properties.
  • Potential Bioactivity: Due to its unique structure, there is hope that this compound might show activity against various tumor cells or pathogenic organisms, making it an exciting subject for further research.

In conclusion, 1-(2-chloroethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one embodies the intersection of synthetic chemistry and pharmacology. Its unique components provide a valuable opportunity for exploration in the quest for new therapeutic agents.