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Prochlorperazine

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Identification
Molecular formula
C20H24ClN3OS
CAS number
58-38-8
IUPAC name
1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone
State
State

At room temperature, Prochlorperazine is typically solid in its base form, particularly appearing as crystalline powder.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
583.00
Boiling point (Kelvin)
856.15
General information
Molecular weight
373.94g/mol
Molar mass
373.8900g/mol
Density
1.4244g/cm3
Appearence

Prochlorperazine is typically found as a white or slightly yellow crystalline powder. It is odorless and has a bitter taste. The compound is used in its salt form, usually as a maleate, for medical applications.

Comment on solubility

Solubility of 1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone

The solubility of 1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone can be influenced by various factors such as temperature, pH, and the nature of the solvent used. Here are some key points regarding its solubility:

  • Solvent Compatibility: This compound tends to be more soluble in organic solvents due to its complex molecular structure, which includes both hydrophobic and hydrophilic groups. Common solvents may include:
    • Dimethyl sulfoxide (DMSO)
    • Ethyl acetate
    • Acetonitrile
  • Aqueous Solubility: In general, the solubility in water may be low owing to the presence of bulky phenothiazine and piperazine structures that hinder dissolution.
  • pH Dependence: The solubility could exhibit a dependency on the pH, particularly due to the hydroxyl groups. An increase in pH could enhance solubility through deprotonation, thus forming more soluble species.

The compound's solubility profile reveals its potential utility in various applications, while also highlighting considerations for formulation in pharmaceuticals or chemical industries. As always, the solubility characteristics must be experimentally determined for precise applications.

Interesting facts

Interesting Facts about 1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone

This compound, often recognized for its significant role in pharmacology, showcases the fascinating intersection of organic chemistry and medicinal applications. Here are several intriguing aspects:

  • Pharmaceutical Applications: This compound is a derivative of phenothiazine, which has been widely employed in the treatment of psychiatric disorders, particularly as an antipsychotic agent. Its structure allows for interactions with neurotransmitter receptors, helping to elucidate its therapeutic effects.
  • Structure-Activity Relationship: The incorporation of various functional groups, such as the 2-chlorophenothiazin moiety and 2-hydroxyethyl substituent, fine-tunes the compound's biological activity. This underscores the importance of structural modifications in enhancing pharmacological efficacy.
  • Synthetic Pathways: The synthesis of this compound involves multi-step reactions, demonstrating the creativity and complexity required in designing drug molecules. Understanding these pathways is essential for both chemists and pharmaceutical scientists aiming to develop new therapeutic agents.
  • Research Opportunities: Ongoing studies continue to explore the full therapeutic potential of this compound. Researchers are examining its effects on various biological targets, adding to the knowledge base of its potential benefits beyond psychotropic applications.
  • Safety Profile: As with many pharmaceutical compounds, understanding the safety and toxicity profile is vital. Studies into adverse effects help guide proper dosage and administration, reflecting the compound's nuanced profile.

In summary, 1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone serves as a prime example of how chemical research can lead to significant advancements in medicine. Its complex structure not only highlights the intricate designs found in nature but also emphasizes the ongoing need for scientific inquiry to unlock its full potential.

Synonyms
ChemDiv1_028213
MixCom6_000405
HMS667C09
STK677510
AKOS005594897
ST038219
SR-01000533949
SR-01000533949-1
1-(2-chloro-10H-phenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone
1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazinyl]ethan-1-one
1-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)-2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHAN-1-ONE