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Prochlorperazine dihydrochloride

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Identification
Molecular formula
C20H24ClN3OS.2HCl
CAS number
52-89-5
IUPAC name
1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone;dihydrochloride
State
State

At room temperature, Prochlorperazine dihydrochloride is a solid compound. It is typically available in the form of tablets, capsules, or injectable solutions. In its pure form, it is a stable compound but should be stored away from light to prevent degradation.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
473.87g/mol
Molar mass
0.0000g/mol
Density
1.3080g/cm3
Appearence

Prochlorperazine dihydrochloride typically appears as a white to pale yellow, crystalline powder. It may also appear as small crystals. It is odorless or has a faint characteristic odor. When exposed to light, it may undergo a slight change in color.

Comment on solubility

Solubility of 1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone; dihydrochloride

The compound 1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone dihydrochloride exhibits notable solubility characteristics, primarily due to its ionic nature. Here are some key points regarding its solubility:

  • Water Solubility: This compound is expected to be soluble in water, owing to the presence of the dihydrochloride which enhances ionic interactions with polar solvents.
  • Solvent Compatibility: It shows compatibility with a range of common solvents, including ethanol and methanol. This is particularly useful for its application in pharmaceutical formulations.
  • Temperature Dependence: Solubility may increase with temperature—a characteristic behavior of many organic compounds.
  • pH Influence: The solubility can also be affected by the pH of the solution, which can alter the degree of ionization of the compound.
  • Possible Challenges: While soluble, certain formulations may require optimization to ensure stability and avoid precipitation.

Overall, it’s crucial to consider these factors when evaluating the solubility of this compound for its intended applications. As with many compounds, the effective solubility can significantly influence its pharmacokinetic properties and overall efficacy in different environments.

Interesting facts

Interesting Facts about 1-(2-chlorophenothiazin-10-yl)-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone; dihydrochloride

This compound, often utilized in the field of medicinal chemistry, is known for its diverse applications in pharmacology. Below are some captivating aspects of this complex molecule:

  • Therapeutic Potential: The compound is derived from phenothiazine, a class of medications primarily used for their antipsychotic and antiemetic properties. Its unique structure may facilitate interactions with various biological targets, making it a subject of research in treating disorders such as schizophrenia and severe anxiety.
  • Structural Complexity: The presence of the 2-chlorophenothiazine and a piperazine moiety introduces steric and electronic variations. This complexity can significantly affect the compound's biological activity and binding affinity, opening new avenues for drug design.
  • Focus on Hydroxyethyl Group: The introduction of a hydroxyethyl group enhances solubility and bioavailability, which are crucial for effective drug formulation. This modification often leads to improved pharmacokinetic properties.
  • Mechanism of Action: Compounds like this one may modulate neurotransmitter systems, particularly dopaminergic and serotonergic pathways, through unique mechanisms, contributing to their therapeutic effects.
  • Research Applications: Beyond its medicinal uses, this compound serves as a valuable tool in research for understanding receptor interactions and cellular mechanisms in pharmacology.

In conclusion, the intricate chemistry and potential applications of this compound make it a fascinating subject of study in both academic and clinical settings. As researchers continue to explore its properties, the possibilities for new therapeutic breakthroughs remain promising.

Synonyms
29573-90-8
Ketone, 2-chlorophenothiazin-10-yl (4-(2-hydroxyethyl)-1-piperazinyl)methyl, dihydrochloride
DTXSID50183751
Phenothiazine, 2-chloro-10-(2-(4-(2-hydroxyethyl)-1-piperazinyl)acetyl)-, dihydrochloride
RefChem:350396
DTXCID90106242