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Chlorpromazine

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Identification
Molecular formula
C17H19ClN2OS
CAS number
50-53-3
IUPAC name
1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one
State
State

Chlorpromazine is typically a solid at room temperature. It is usually found in the form of its hydrochloride salt for pharmaceutical uses, which is more stable and soluble, making it suitable for its role in medication forms such as tablets and injections.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
402.80
Boiling point (Kelvin)
675.95
General information
Molecular weight
318.86g/mol
Molar mass
318.8550g/mol
Density
1.2895g/cm3
Appearence

Chlorpromazine is a solid substance that may appear as white or off-white crystals or powder. It is sensitive to light and air, which can lead to discoloration. Care should be taken to store it in conditions that minimize exposure to these elements to maintain its stability and appearance.

Comment on solubility

Solubility of 1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one

The solubility of 1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one in various solvents is an important aspect that dictates its applicability in pharmaceutical and chemical formulations. Factors influencing solubility include:

  • Polarity: The presence of hydroxyl groups increases polarity, making the compound potentially more soluble in polar solvents like water.
  • Temperature: Generally, solubility increases with temperature. This means higher temperatures might enhance the solubility of this compound in chosen solvents.
  • pH Levels: Changes in pH can affect the ionization of functional groups, thereby altering solubility in aqueous solutions.
  • Solvent Choice: Solubility can vary greatly depending on the solvent; this compound may demonstrate higher solubility in organic solvents rather than in aqueous solutions.

It is essential to conduct experiments to determine the exact solubility metrics, as "solubility can vary widely under different conditions." Thus, evaluating the compound’s behavior in different environments is critical for its application in drug formulation.

Furthermore, understanding the interactions between this compound and solvent molecules can lead to improved formulations and efficacy in its application. Hence, thorough testing for solubility profiles in various conditions is recommended for optimal utilization.

Interesting facts

Interesting Facts about 1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one

This compound, belonging to the class of phenothiazine derivatives, has captured the interest of researchers due to its potential pharmacological properties.

Pharmacological Significance

  • Antipsychotic Properties: Phenothiazines are known for their role as antipsychotics, and this compound may exhibit similar effects, making it relevant in the treatment of various psychiatric disorders.
  • Anti-inflammatory Activity: Preliminary studies suggest that derivatives of this compound can possess anti-inflammatory properties, which can be helpful in treating conditions related to inflammation.
  • Potential for Development: The unique structure, particularly the presence of the piperazine ring, opens avenues for modifying the compound to enhance its therapeutic efficacy.

Chemical Structure and Characteristics

The intricate structure of this compound allows for a variety of interactions within biological systems. Key features include:

  • Chlorine Substituent: The 2-chlorophenyl group can influence the biological activity and the pharmacokinetics of the compound.
  • Hydroxyethyl Group: The presence of the hydroxyethyl side chain may contribute to solubility and interaction with biological targets.
  • Piperazine Moiety: This heterocyclic component is often associated with increased binding affinity in receptor interactions.

Research and Potential Applications

As scientists continue to explore the therapeutic potentials of this compound, several areas of application have emerged:

  • Neuropharmacology: Understanding how this compound interacts within the central nervous system.
  • Chemotherapy: Investigating its role in enhancing the effects of anticancer drugs.
  • Drug Design: Utilizing computational chemistry to optimize its structure for better efficacy and reduced side effects.

As a student or researcher, studying compounds like 1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one can provide invaluable insights into the future of pharmaceutical development and therapeutic innovation.