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Prochlorperazine dihydrochloride

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Identification
Molecular formula
C20H24ClN3O·2HCl
CAS number
813-86-9
IUPAC name
1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one;dihydrochloride
State
State

At room temperature, prochlorperazine dihydrochloride is generally in a solid state, specifically as a crystalline powder. It is generally stable under standard storage conditions.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
458.44g/mol
Molar mass
458.8790g/mol
Density
1.2497g/cm3
Appearence

Prochlorperazine dihydrochloride typically appears as a white or off-white crystalline powder. It is odorless or may have a slight odor. It is also hygroscopic, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of 1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one; dihydrochloride

The solubility of 1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one; dihydrochloride is an important consideration for its application in pharmaceuticals. Here are some key points regarding its solubility:

  • Water Solubility: As a dihydrochloride salt, this compound is generally expected to have increased solubility in water compared to its neutral form, aiding in formulation.
  • Solvent Variability: Solubility might vary significantly depending on the pH of the solution and the presence of other solvents or solutes.
  • Temperature Effects: The solubility could also be influenced by temperature, where higher temperatures may enhance dissolution.
  • Impact of Functional Groups: The presence of functional groups such as hydroxyl and piperazine moieties suggest that hydrogen bonding and dipole interactions could play a role in solubility properties.

In conclusion, understanding the solubility characteristics of this compound is vital for its efficacy in drug formulation and delivery. As with many chemicals, solubility is influenced by a combination of factors, including chemical structure, environmental conditions, and molality of the solution.

Interesting facts

Interesting Facts about 1-(2-chlorophenothiazin-10-yl)-3-[4-(2-hydroxyethyl)piperazin-1-yl]propan-1-one; dihydrochloride

This compound is a fascinating example of a phenothiazine derivative, known for its wide range of applications in medicinal chemistry. Here are some noteworthy points:

  • Pharmaceutical Relevance: Phenothiazines have been extensively studied for their utility as antipsychotic agents. The presence of a chlorophenyl group adds unique properties, potentially enhancing their therapeutic efficacy.
  • Mechanism of Action: Compounds in this class often function as dopamine receptor antagonists, highlighting a significant mechanism in the treatment of schizophrenia and other mental health disorders.
  • Versatile Chemistry: The piperazine ring and hydroxyethyl moiety offer sites for further functionalization, which can be critical in optimizing pharmacokinetic and pharmacodynamic properties.
  • Structure-Activity Relationship: Understanding how changes in this compound's structure can influence its activity provides insights into medicinal chemistry and lead to the development of more effective drugs.
  • Safety and Efficacy: Like many pharmaceutical compounds, the study of its side effects and therapeutic index is vital in drug development, ensuring safety for patients.

As scientists explore the potential of this compound, they continue to emphasize the importance of innovative approaches to tackle complex mental health issues, reminding us that the relationship between structure and function remains a cornerstone of drug discovery.

Synonyms
Ketone, 2-chlorophenothiazin-10-yl 2-(4-(2-hydroxyethyl)-1-piperazinyl)ethyl, dihydrochloride
28747-82-2
DTXSID70182923
Phenothiazine, 2-chloro-10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propionyl)-, dihydrochloride
RefChem:350397
DTXCID10105414