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Promazine

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Identification
Molecular formula
C17H20ClN3OS
CAS number
58-40-2
IUPAC name
1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one
State
State

At room temperature, promazine is typically in a solid state, often found as a powder or in crystalline form.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
575.15
Boiling point (Kelvin)
848.30
General information
Molecular weight
284.88g/mol
Molar mass
284.3920g/mol
Density
1.2100g/cm3
Appearence

Promazine appears as a solid crystalline powder that can range from white to off-white in color. It is often used in its hydrochloride form for medicinal purposes.

Comment on solubility

Solubility of 1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one

The solubility of the compound 1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one can be influenced by several factors such as polarity, molecular structure, and the presence of functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple electronegative atoms, such as chlorine in the phenothiazine moiety, may affect the polarity of the compound. Compounds with higher polarity typically exhibit greater solubility in polar solvents.
  • Functional Groups: The diethylamino group is known to increase solubility in polar organic solvents. However, the overall solubility will depend on the balance between hydrophobic and hydrophilic regions within its structure.
  • Common Solvents: This compound may be soluble in solvents like ethanol and dimethyl sulfoxide (DMSO), but solubility in water may be limited due to its hydrophobic characteristics.

In summary, while specific solubility data may require empirical testing, it can be expected that, due to the molecular structure of 1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one, its solubility in polar solvents will likely be enhanced, while non-polar solvents may show limited solubility.

Interesting facts

Interesting Facts about 1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one

This compound, known for its complex molecular structure, has garnered attention in various fields of research and application. Here are some fascinating aspects about 1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one:

  • Pharmacological Significance: This compound falls under the category of phenothiazine derivatives, which are essential in medicinal chemistry. It has potential applications in the development of antipsychotic drugs, showcasing its relevance in treating mental health disorders.
  • Structural Diversity: The unique structure of this compound includes a chlorinated phenothiazine moiety. The combination of different functional groups enhances its biological activity and reactivity.
  • Chirality: The compound features a chiral center, allowing for the possibility of enantiomers. This is particularly significant, as different enantiomers can have varying pharmacological effects.
  • Mechanism of Action: Researchers are exploring how the structural components interact at the molecular level. It is believed that the amino group may participate in binding to neurotransmitter receptors, contributing to its psychotropic effects.
  • Research Potential: Ongoing studies aim to systematically analyze its interaction with various biological targets, potentially leading to the discovery of novel therapeutic applications.

Quote from the Field

As stated in recent studies, “The exploration of phenothiazine derivatives continues to pave the way for innovative treatments in psychiatry.”

This compound exemplifies the intricate relationship between chemistry and medicine, proving that a single molecular change can lead to remarkable variations in biological activity. It's an exciting time for researchers in chemical sciences, as the potential for new discoveries seems limitless!

Synonyms
CHLORACYZINE
Chloracizine
Chloracizin
Chlorazicin
Chlorazicine
Chloroacizin
Chloroacizine
Chloroacyzin
Chloracizinum
Khloratsizin
Cloracizina
Chloracysin
Chloracyzinum
Chlorocizin
Chloracyzine [INN:DCF]
G-020
Chloracyzinum [INN-Latin]
Cloracizina [INN-Spanish]
UNII-TZ913SWN6M
BRN 0042353
DTXSID6046183
CHLORACIZINE [MI]
CHLORACYZINE [INN]
2-Chloro-10-(N,N-diethyl-beta-alanyl)phenothiazine
Phenothiazine, 2-chloro-10-(N,N-diethyl-.beta.-alanyl)-
DTXCID4026183
10H-Phenothiazine, 2-chloro-10-(3-(diethylamino)-1-oxopropyl)-
Phenothiazine, 2-chloro-10-(N,N-diethyl-beta-alanyl)-
Chloracyzinum (INN-Latin)
Cloracizina (INN-Spanish)
2-Chloro-10-(N,N-diethyl-.beta.-alanyl)phenothiazine
chloracysine
10H-Phenothiazine, 2-chloro-10-(3-(diethylamino)-1-oxopropyl)-(9CI)
4-27-00-01315 (beilstein handbook reference)
zzkwnlzuyagvot-uhfffaoysa-n
800-22-6
1-(2-chlorophenothiazin-10-yl)-3-(diethylamino)propan-1-one
2-Chloro-10-(3-diethylaminopropionyl)phenothiazine
TZ913SWN6M
NCGC00160486-01
Oprea1_047986
MLS006011648
SCHEMBL309939
CHEMBL290624
Tox21_111848
1-(2-Chloro-10H-phenothiazin-10-yl)-3-(diethylamino)-1-propanone
STL325265
AKOS001491164
CAS-800-22-6
SMR004703406
AB00918350-05
BRD-K99124663-001-01-1
Q27290492
1-(2-chloro-10H-phenothiazin-10-yl)-3-(diethylamino)propan-1-one