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Clonazolam

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Identification
Molecular formula
C17H12ClN3O
CAS number
33887-02-4
IUPAC name
1-(2-chlorophenyl)-2-imidazol-1-yl-ethanone
State
State
Clonazolam is typically a solid at room temperature, presented as a fine crystalline powder. Its solid state is due to its molecular structure and inter-molecular forces present in the compound.
Melting point (Celsius)
0.00
Melting point (Kelvin)
273.15
Boiling point (Celsius)
398.70
Boiling point (Kelvin)
671.85
General information
Molecular weight
353.15g/mol
Molar mass
353.1530g/mol
Density
1.4580g/cm3
Appearence

Clonazolam typically appears as a crystalline solid. It is usually a white or off-white powder, but its appearance can vary depending on the form and purity of the compound. The crystals can be either fine or coarse.

Comment on solubility

Solubility of 1-(2-chlorophenyl)-2-imidazol-1-yl-ethanone

The solubility of 1-(2-chlorophenyl)-2-imidazol-1-yl-ethanone is influenced by its molecular structure and the presence of functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of the imidazole ring and the chlorophenyl group may contribute to variations in polarity, affecting solubility in polar versus non-polar solvents.
  • Solvent Compatibility: This compound is expected to be soluble in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Acetonitrile
    • Ethanol
    • Chloroform
  • Limited Aqueous Solubility: Generally, compounds with such aromatic and heteroaromatic structures can exhibit limited solubility in water.
  • Influence of Temperature: As with many organic compounds, solubility tends to increase with temperature, making hot solvents more effective for dissolution.

In summary, the solubility of 1-(2-chlorophenyl)-2-imidazol-1-yl-ethanone is likely to be moderate in organic solvents while showing limitations in water, highlighting the importance of solvent selection in laboratory settings.

Interesting facts

Interesting Facts about 1-(2-Chlorophenyl)-2-imidazol-1-yl-ethanone

1-(2-Chlorophenyl)-2-imidazol-1-yl-ethanone is an intriguing compound in the field of medicinal chemistry. Here are some notable aspects that highlight its significance:

  • Pharmacological Potential: This compound is under investigation for its potential pharmacological applications, particularly in the realm of cancer therapy. Its unique structure facilitates interaction with biological targets, making it a candidate for developing novel therapeutic agents.
  • Heterocyclic Chemistry: It contains an imidazole ring, which is a common motif in many biologically active compounds. Heterocycles like imidazole are critical for drug design due to their role in binding to enzymes and receptors in the body.
  • Substituent Influence: The presence of the 2-chlorophenyl group can significantly influence the compound's biological activity. Chlorine substituents often enhance the lipophilicity and reactivity of compounds, potentially improving their efficacy in therapeutic applications.
  • Research Interest: Researchers are keenly exploring derivatives of this compound. Modifying different aspects of its structure can lead to the discovery of new compounds with improved selectivity and reduced side effects.
  • Safety and Toxicology: Understanding the safety profile of such compounds is crucial. Investigating toxicity, metabolism, and the mechanisms of action helps to establish a balance between efficacy and safety in drug development.

In conclusion, 1-(2-Chlorophenyl)-2-imidazol-1-yl-ethanone serves as a compelling study subject for future research. Its unique properties and potential applications create an exciting avenue for scientists and students alike, encouraging further exploration into its synthetic routes and biomedical implications.

Synonyms
CHEMBL162222
SCHEMBL10878611
SCHEMBL29669830