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Brotizolam

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Identification
Molecular formula
C20H17Cl2N3
CAS number
57801-95-3
IUPAC name
1-(2-chlorophenyl)-N-[[4-[[(2-chlorophenyl)methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine
State
State

At room temperature, Brotizolam exists as a crystalline solid.

Melting point (Celsius)
122.50
Melting point (Kelvin)
395.65
Boiling point (Celsius)
290.40
Boiling point (Kelvin)
563.55
General information
Molecular weight
470.36g/mol
Molar mass
470.3600g/mol
Density
1.2850g/cm3
Appearence

Brotizolam is a white to off-white crystalline powder. It is typically provided in its solid form.

Comment on solubility

Solubility Characteristics

The compound 1-(2-chlorophenyl)-N-[[4-[[(2-chlorophenyl)methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine exhibits unique solubility properties that are crucial for its application in various scenarios. Understanding its solubility can provide insights into its behavior in different environments.

Key Solubility Insights

  • Polar vs. Nonpolar Solvents: The presence of multiple aromatic rings typically suggests that the compound may have limited solubility in polar solvents, while potentially being more soluble in nonpolar solvents due to hydrophobic interactions.
  • Aromatic Influence: The 2-chlorophenyl groups can affect solubility due to their electron-withdrawing nature, likely limiting solubility in water.
  • Functional Groups: Moreover, the amine groups present may introduce some degree of hydrogen bonding with solvents, which could enhance solubility in alcohols or similar acceptors.
  • Temperature Dependency: As with many organic compounds, solubility might vary significantly with temperature, often increasing at elevated temperatures.

It's important to remember that the solubility of this compound should be assessed in the context of specific solvent systems, as empirical testing is crucial to understand its behavior fully. As a concise takeaway, it can be said that "the solubility of 1-(2-chlorophenyl)-N-[[4-[[(2-chlorophenyl)methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine is influenced significantly by its structural components, polarities, and the environment in which it is dissolved."

Interesting facts

Interesting Facts about 1-(2-chlorophenyl)-N-[[4-[[(2-chlorophenyl)methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine

This compound, with its intricate structure, presents a fascinating study in the realm of organic chemistry and medicinal applications. Here are some notable points:

  • Structural Complexity: The presence of both a bicyclic structure and multiple aromatic rings introduces significant complexity to this compound, which can affect its chemical behavior and interactions.
  • Chlorine Substituents: The 2-chlorophenyl groups are pivotal in medicinal chemistry. Chlorinated compounds often demonstrate unique biological properties and can influence the lipophilicity and binding affinity of the molecule.
  • Potential Applications: Compounds of this nature may exhibit interesting pharmacological activities, making them subjects of important research in drug development. This includes investigations into antipsychotic and antidepressant properties.
  • Intermolecular Interactions: The complex arrangement of functional groups can pave the way for intriguing intermolecular forces, impacting solubility and reactivity profiles.
  • Research and Development: Despite its potential, research into such compounds often requires careful synthesis and characterization to ensure safety and efficacy in therapeutic applications.

As the scientific community continues to delve into the intricacies of organic compounds, the study of 1-(2-chlorophenyl)-N-[[4-[[[2-chlorophenyl)methylamino]methyl]-1-bicyclo[2.2.2]octanyl]methyl]methanamine represents both the challenges and the excitements associated with chemical exploration.