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Cimetidine

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Identification
Molecular formula
C10H16ClN5
CAS number
70393-28-3
IUPAC name
1-[(2-chlorophenyl)methyl]-2-methyl-guanidine
State
State

At room temperature, Cimetidine is typically in a solid state as a crystalline powder.

Melting point (Celsius)
141.50
Melting point (Kelvin)
414.65
Boiling point (Celsius)
477.10
Boiling point (Kelvin)
750.25
General information
Molecular weight
252.72g/mol
Molar mass
252.3390g/mol
Density
0.8673g/cm3
Appearence

Cimetidine is a white to pale yellow crystalline powder. It is practically odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 1-[(2-chlorophenyl)methyl]-2-methyl-guanidine

The solubility of 1-[(2-chlorophenyl)methyl]-2-methyl-guanidine can vary significantly based on the solvent used and the environmental conditions. Typically, the solubility behavior of this compound is influenced by the following factors:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents like water.
  • Temperature: Raising the temperature often increases the solubility of solids in liquids, allowing for greater dissolution rates.
  • pH Levels: Since guanidines can exhibit basic behavior, solubility may change depending on the acidity or basicity of the medium.
  • Presence of Other Solutes: The solubility can be affected by other dissolved substances through phenomena such as salting out or complexation.

In general, you can expect that:

  • 1-[(2-chlorophenyl)methyl]-2-methyl-guanidine may have limited water solubility due to its hydrophobic aromatic group.
  • However, its guanidine structure may impart some solubility in organic solvents.

Overall: "Solubility is a critical characteristic that dictates the utility and application of chemical compounds." Experimentation with various solvents will provide more definitive insights into its solubility profile.

Interesting facts

Interesting Facts about 1-[(2-chlorophenyl)methyl]-2-methyl-guanidine

1-[(2-chlorophenyl)methyl]-2-methyl-guanidine is a fascinating compound with several intriguing characteristics and applications. Here are some key points about this chemical:

  • Structure and Functionality: This compound belongs to the guanidine class, which is known for its basicity and nucleophilic properties. The presence of the 2-chlorophenyl group introduces interesting electronic properties that can influence the compound's reactivity.
  • Biological Activity: Compounds similar to 1-[(2-chlorophenyl)methyl]-2-methyl-guanidine are often explored for their pharmacological potential. Studies have indicated that guanidine derivatives can exhibit activities such as antimicrobial, antidiabetic, and neuromodulatory effects.
  • Synthesis Challenges: The synthesis of this compound may involve several steps. Chemists often need to carefully choose reaction conditions to ensure that the desired product is obtained with minimal side reactions.
  • Research Applications: Due to its unique structure, this compound can serve as a valuable starting material in drug design and development. Researchers use it to modify existing pharmacophores or create new derivatives for various therapeutic applications.
  • Environmental Considerations: Like many synthetic compounds, the environmental impact of its production and degradation should not be overlooked. Researchers are keen to develop greener synthesis methods to minimize waste and toxicity.
  • Analytical Techniques: The study of such compounds often employs advanced analytical techniques including NMR (Nuclear Magnetic Resonance), HPLC (High-Performance Liquid Chromatography), and MS (Mass Spectrometry), which help in understanding their structure and behavior.

In summary, 1-[(2-chlorophenyl)methyl]-2-methyl-guanidine is not only a compound of interest for academic research but also provides insight into the broader implications of chemical structure on biological activity and environmental sustainability.

Synonyms
BRN 2837430
GUANIDINE, 2-(o-CHLOROBENZYL)-1-METHYL-
2-(o-Chlorobenzyl)-1-methylguanidine
3911-37-3
Guanidine, N-((2-chlorophenyl)methyl)-N'-methyl-
DTXSID80192356
DTXCID90114847
SCHEMBL973283
AKOS011645132