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Metformin hydrochloride

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Identification
Molecular formula
C4H11N5
CAS number
1115-70-4
IUPAC name
1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine;sulfuric acid
State
State

At room temperature, metformin hydrochloride exists in a solid state. It is supplied in the form of tablets or as a dry powder for pharmaceutical formulations.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
165.63g/mol
Molar mass
165.6250g/mol
Density
1.7830g/cm3
Appearence

Metformin hydrochloride is typically a white crystalline powder. It may appear slightly off-white due to impurities or environmental factors. The powder has no odor.

Comment on solubility

Solubility of 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine; sulfuric acid (C4H11N5)

The solubility of 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine in various solvents can be quite significant, given its chemical structure. This compound contains both hydrophobic and hydrophilic regions, which influence its interaction with different solvents.

Factors Affecting Solubility

  • Polarity: Due to the presence of the guanidine functional group, the compound exhibits polar characteristics, allowing it to dissolve readily in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water enhances its solubility, making it more favorable in aqueous environments.
  • Steric Effects: The bulky 2-chlorophenyl group can hinder solubility in non-polar solvents, leading to preferential solubility in polar organic solvents.

In practical applications, the solubility can be summarized as follows:

  1. Highly soluble in water: The polar nature of the compound allows it to interact well with water molecules.
  2. Moderately soluble in organic solvents: While it can dissolve in various organic solvents, the extent of solubility will depend on the solvent’s polarity.
  3. Limited solubility in non-polar solvents: The compound may not dissolve effectively in non-polar solvents, limiting its use in certain applications.

Overall, the solubility characteristics reveal the compound's potential for diverse applications in various chemical environments while also influencing its reactivity and behavior in solution.

Interesting facts

Interesting Facts About 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine; sulfuric acid

This compound is a fascinating example of a guanidine derivative, carrying significant importance in various fields, particularly in medicinal chemistry and pharmacology. Here are some intriguing aspects:

  • Pharmacological Potential: Guanidine derivatives like this one have been studied for their potential therapeutic effects. Some have been found to be effective in modulating neurotransmitter levels, thereby demonstrating promise in treating various neurological disorders.
  • Structure-Activity Relationship (SAR): The unique structure of this compound, particularly the incorporation of the 2-chlorophenyl group, allows for enhanced interactions with biological targets, opening up avenues for designing new drugs with improved efficacy.
  • Applications in Research: This type of compound is regularly employed in research to understand cellular signaling mechanisms. Its ability to mimic certain biological interactions makes it an invaluable tool for scientists across various disciplines.
  • Complex Synthesis: The synthesis of this compound illustrates the challenges and creativity required in organic chemistry. Chemical reactions must be carefully crafted to introduce each functional group with specific reactivity in mind.

Furthermore, guanidine derivatives are often studied for their roles in catalysis and as intermediates in organic synthesis, showcasing the versatility of such compounds in the laboratory. As stated by one prominent researcher, “The diversity within guanidine derivatives exemplifies the beauty of chemistry—simple changes can lead to significant differences in properties and applications.”

In summary, 1-[(2-chlorophenyl)methyl]-2,3-dimethyl-guanidine; sulfuric acid represents not only a specific chemical compound but also a gateway to exploring numerous scientific inquiries across various fields.

Synonyms
o-Chlorobetanidine sulfate
73-64-3
1-[(2-chlorophenyl)methyl]-2,3-dimethylguanidine;sulfuric acid
DTXSID50993756
GUANIDINE, 1-(o-CHLOROBENZYL)-2,3-DIMETHYL-, SULFATE (2:1)
Guanidine, N-((2-chlorophenyl)methyl)-N',N''-dimethyl-, sulfate (2:1)
Sulfuric acid--N-[(2-chlorophenyl)methyl]-N',N''-dimethylguanidine (1/2)