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Tadalafil

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Identification
Molecular formula
C22H19N3O4
CAS number
171596-29-5
IUPAC name
1-[2-(diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazole-5-carbonitrile
State
State

At room temperature, Tadalafil is a solid.

Melting point (Celsius)
298.00
Melting point (Kelvin)
571.00
Boiling point (Celsius)
944.30
Boiling point (Kelvin)
1 217.45
General information
Molecular weight
389.41g/mol
Molar mass
389.4070g/mol
Density
1.2300g/cm3
Appearence

Tadalafil appears as a white to off-white crystalline powder. It's not soluble in water but freely dissolves in organic solvents such as ethanol and dimethyl sulfoxide.

Comment on solubility

Solubility of 1-[2-(diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazole-5-carbonitrile

The solubility of 1-[2-(diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazole-5-carbonitrile is influenced by several factors, notably the compound's molecular structure and polarity. Here are some key points to consider:

  • Polarity: This compound features various functional groups, such as the diethylamino group and the ethoxyphenyl moiety, which suggest that it may exhibit moderate polarity.
  • Solvent Interaction: Generally, compounds with higher polarity tend to be soluble in polar solvents, while non-polar solvents are more suited for non-polar compounds. Expect potential solubility in solvents like water and alcohols.
  • Hydrophobic Regions: The presence of phenyl and ethyl groups implies sections of the molecule may contribute to hydrophobic interactions, potentially affecting solubility.
  • Applications Impact: The solubility profiles can significantly affect its biological activity and pharmacokinetics in various applications, especially in pharmaceutical contexts.

Overall, while the exact solubility of this compound would need to be determined experimentally, the interplay of polar and hydrophobic characteristics suggests that a more detailed solubility study would yield useful insights for its practical applications.

Interesting facts

Interesting Facts about 1-[2-(diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazole-5-carbonitrile

This compound is a fascinating member of the benzimidazole family, which is renowned for its diverse applications in various fields such as pharmaceuticals, agricultural science, and material science. Here are some intriguing aspects of this compound:

  • Pharmacological Significance: Benzimidazole derivatives are often explored for their biological activities, including anti-cancer, anti-inflammatory, and anti-microbial properties. This compound, with its unique structure, may hold potential therapeutic applications.
  • Structure-Activity Relationship: The presence of the diethylamino group suggests potential modulations of the compound's pharmacokinetics and pharmacodynamics. This can influence the compound's solubility and interaction with biological targets.
  • Synthetic Versatility: The complexity of this compound's structure allows for synthesis through various synthetic pathways, making it an exciting subject for research. Chemists can develop new methodologies to enhance yields or modify the structure for better efficacy.
  • Interdisciplinary Applications: Beyond medicinal chemistry, compounds like this could have utility in fields such as dye synthesis and electronic materials. The incorporation of ethoxy and cyano groups may impart interesting electronic properties.

In summary, 1-[2-(diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazole-5-carbonitrile is not just a chemical compound; it is a gateway to exploring various avenues in scientific research and industry. Its unique combination of structural elements opens the door to potential innovations in drug discovery and material design.