Skip to main content

Mefloquine

ADVERTISEMENT
Identification
Molecular formula
C17H16ClF3N2O
CAS number
53230-10-7
IUPAC name
1-[2-(diethylamino)ethyl]-N-(4-ethoxyphenyl)-5-methylsulfonyl-benzimidazol-2-amine
State
State

At room temperature, mefloquine is typically in a solid state.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
467.00
Boiling point (Kelvin)
740.15
General information
Molecular weight
356.47g/mol
Molar mass
356.4660g/mol
Density
1.3100g/cm3
Appearence

Mefloquine typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility Insights for 1-[2-(diethylamino)ethyl]-N-(4-ethoxyphenyl)-5-methylsulfonyl-benzimidazol-2-amine

Understanding the solubility of 1-[2-(diethylamino)ethyl]-N-(4-ethoxyphenyl)-5-methylsulfonyl-benzimidazol-2-amine is essential for its applications in chemical and medicinal fields. Factors influencing its solubility include:

  • Polarity: The presence of polar functional groups, such as the sulfonyl and amine groups, can enhance solubility in polar solvents.
  • Hydrophobic Character: The ethoxy and diethylamino groups may contribute to hydrophobic interactions, potentially limiting solubility in water but increasing it in organic solvents.
  • pH Sensitivity: Changes in pH can affect the protonation state of the amine group, thereby altering solubility in aqueous solutions.
  • Temperature: Typically, increased temperature can facilitate higher solubility for many compounds, though exceptions exist.

As a practical note, “solubility is a key aspect that dictates the behavior of any compound in solution.” For this specific compound, expect variability in solubility based on the solvent system chosen, highlighting the importance of thorough solvent screening in experimental protocols. Moreover, the compound's solubility may also influence its bioavailability in pharmacological applications, making it a critical parameter to evaluate.

Interesting facts

Interesting Facts about 1-[2-(diethylamino)ethyl]-N-(4-ethoxyphenyl)-5-methylsulfonyl-benzimidazol-2-amine

This intriguing compound belongs to the class of benzimidazole derivatives, which are notable for their diverse biological activities. Researchers have been particularly interested in such compounds due to their potential therapeutic applications. Here are some fascinating aspects:

  • Biological Relevance: Compounds containing the benzimidazole structure are known for their anti-inflammatory, antiviral, and antifungal properties. The presence of substituents like the diethylamino group can enhance these activities, possibly leading to novel pharmacological applications.
  • Structure Diversity: The unique combination of various functional groups in this compound, including the methylsulfonyl and ethoxy phenyl moieties, can contribute to altered solubility and reactivity, opening pathways for targeted drug design.
  • Synthesis Challenges: The synthetic route for such complex structures is often intricate and may require multiple steps of transformation. Chemists strive to optimize yield and purity while minimizing by-products, making synthetic strategies a crucial area of study.
  • Role in Research: This compound can serve as a lead compound for further modifications aimed at enhancing efficacy or reducing side effects in drug development processes, showcasing the dynamic nature of chemical research.

As you explore the fascinating world of organic compounds, don’t underestimate the significance of intricate structures like this one. Each molecular design carries potential that could lead to groundbreaking advancements in medicine and beyond!

Synonyms
BRN 0946155
BENZIMIDAZOLE, 1-(2-(DIETHYLAMINO)ETHYL)-5-(METHYLSULFONYL)-2-p-PHENETIDINO-
15451-95-3
DTXSID10165654
1-(2-(Diethylamino)ethyl)-5-(methylsulfonyl)-2-p-phenetidinobenzimidazole
5-25-13-00105 (Beilstein Handbook Reference)
DTXCID8088145