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Diazepam

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Identification
Molecular formula
C16H13ClFN3O
CAS number
439-14-5
IUPAC name
1-[2-(dimethylamino)ethyl]-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-2-one
State
State

At room temperature, diazepam is typically found as a crystalline solid. When used in medication, it is also found in solution or tablet form.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
305.50
Boiling point (Kelvin)
578.65
General information
Molecular weight
284.75g/mol
Molar mass
284.7480g/mol
Density
1.3060g/cm3
Appearence

Diazepam appears as a colorless to light yellow crystalline compound when pure. It is often available in various dosage forms, including tablets and injectable solutions, and these forms might range in color due to excipients used.

Comment on solubility

Solubility of 1-[2-(dimethylamino)ethyl]-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-2-one

The solubility of 1-[2-(dimethylamino)ethyl]-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-2-one in different solvents can vary significantly due to its complex structure. This compound, being a quaternary ammonium salt, often displays the following solubility characteristics:

  • Highly Soluble in Polar Solvents: Compounds with quaternary ammonium structures typically exhibit good solubility in polar solvents such as water and ethanol, owing to their ionic nature.
  • Poor Solubility in Non-Polar Solvents: Conversely, solubility in organic solvents like hexane or toluene is often low, as the ionic interactions are not favored in non-polar environments.
  • Temperature Dependence: The solubility may also be temperature-dependent; increases in temperature can enhance solubility in many instances.
  • pH Influence: The solubility profile can be affected by the pH of the solution, particularly in physiological contexts where the ionization state of the compound may change.

In conclusion, understanding the solubility of this compound is crucial for its applications, as it influences its bioavailability, formulation, and overall effectiveness. As stated in chemical literature, "The solubility of a compound is a fundamental property that dictates its behavior in various environments." Thus, in-depth solubility studies are vital for optimizing its use in synthetic and therapeutic contexts.

Interesting facts

Interesting Facts About 1-[2-(dimethylamino)ethyl]-5-phenyl-7-(trifluoromethyl)-3H-1,4-benzodiazepin-4-ium-2-one

This compound, often referred to in the realm of medicinal chemistry, belongs to the benzodiazepine class, known for their complex structures and diverse pharmacological properties. Here are some fascinating insights:

  • Medicinal Applications: Benzodiazepines are primarily associated with their use in treating conditions such as anxiety, insomnia, and seizures. This specific compound's unique structure may contribute to its efficacy in these areas.
  • Structure-Activity Relationships: The presence of the dimethylamino group is intriguing as it can influence the binding affinity of the compound to neuronal receptors. The substitutions on the phenyl group and the trifluoromethyl moiety can also modulate its pharmacodynamics.
  • Trifluoromethyl Group: The inclusion of a trifluoromethyl group is noteworthy because it not only affects the lipophilicity and metabolic stability of the compound but also plays a role in enhancing its biological activity. In the arena of pharmaceuticals, trifluoromethylated compounds often display unique properties that stand out in drug discovery.

It's essential to emphasize the significance of this compound in the field of drug design and development. Researchers are continuously exploring how subtle changes in molecular structure can lead to profound variations in therapeutic outcomes. As one benzodiazepine among many, this compound showcases the intricate balance between structure and function that is central to medicinal chemistry.

In the words of a seasoned chemist: "In the realm of organic synthesis, every atom counts, and understanding how they interact can lead to revolutionary therapies."

Ultimately, this compound is not just a chemical entity; it represents the culmination of years of research aimed at bettering human health through innovative medicinal products.