Ketorolac | Solubility of Things

Identification

Molecular formula

C₁₉H₂₄N₂O₃

CAS number

74103-06-3

IUPAC name

[1-[2-(dimethylamino)ethyl]pyrrol-2-yl]-(2-methoxyphenyl)methanone

State

At room temperature, ketorolac exists as a solid powder.

Melting point (Celsius)

158.00

Melting point (Kelvin)

431.15

Boiling point (Celsius)

410.70

Boiling point (Kelvin)

683.90

General information

Molecular weight

349.42g/mol

Molar mass

349.4220g/mol

Density

1.2482g/cm³

Appearence

Ketorolac typically appears as a white to off-white crystalline powder. It is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic properties.

Comment on solubility

Solubility of 1-[2-(dimethylamino)ethyl]pyrrol-2-yl]-(2-methoxyphenyl)methanone

The solubility of 1-[2-(dimethylamino)ethyl]pyrrol-2-yl]-(2-methoxyphenyl)methanone can be quite intriguing due to its complex structure. This compound features both polar and non-polar functional groups, which can affect its interaction with solvents. Here are some key points to consider regarding its solubility:

Water Solubility: Typically, compounds with significant hydrophobic character may have low solubility in water. However, the presence of the dimethylamino group may enhance water solubility to some extent.
Organic Solvents: The compound is expected to be soluble in various organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), where it can engage in hydrogen bonding and dipole interactions.
pH Dependency: The solubility may vary with changes in pH, particularly due to the basic nature of the dimethylamino group which can be protonated in acidic conditions, potentially increasing solubility in aqueous acidic solutions.
Temperature Effects: An increase in temperature might lead to higher solubility in organic solvents, which is generally true for many organic compounds.

In conclusion, while the exact solubility profile can depend on several factors such as temperature and solvent composition, it is clear that this compound's unique structure offers a blend of hydrophilic and hydrophobic characteristics, influencing its overall solubility behavior.

Interesting facts

Interesting Facts About [1-[2-(dimethylamino)ethyl]pyrrol-2-yl]-(2-methoxyphenyl)methanone

[1-[2-(dimethylamino)ethyl]pyrrol-2-yl]-(2-methoxyphenyl)methanone, a compound with a unique structure, has garnered attention in various fields of research and industry. Here are some fascinating insights about this compound:

Chemical Structure: This compound features a pyrrolidine ring combined with a methanone moiety, showcasing an interesting blend of different functional groups that contribute to its chemical reactivity.
Potential Applications: Research indicates that compounds with similar structures may exhibit promising pharmacological properties. They could serve as templates for drug development in treating conditions such as neurodegenerative disorders.
Dimethylamino Group: The presence of the dimethylamino group is known for enhancing biological activity. This group often increases the lipophilicity of compounds, which can facilitate their ability to cross cellular membranes and access targeted sites in the body.
Research Relevance: The increasing interest in derivatives of this compound can be attributed to their potential impact in medicinal chemistry, particularly in the development of novel therapeutic agents.
Innovative Modifications: Scientists are continuously exploring structural modifications to optimize the activity of compounds like [1-[2-(dimethylamino)ethyl]pyrrol-2-yl]-(2-methoxyphenyl)methanone, leading to advances in drug efficacy and specificity.

In conclusion, [1-[2-(dimethylamino)ethyl]pyrrol-2-yl]-(2-methoxyphenyl)methanone stands as an exciting avenue for exploration in the realm of chemical research. Its intriguing structure and potential applications emphasize the importance of continuous study in the chemical sciences.