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Flecainide

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Identification
Molecular formula
C22H28F1N2O3
CAS number
54143-55-4
IUPAC name
1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium;bromide
State
State

Flecainide is typically in a solid state at room temperature. It is commonly encountered as a crystalline powder.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
323.00
Boiling point (Kelvin)
596.15
General information
Molecular weight
362.22g/mol
Molar mass
362.2240g/mol
Density
1.3600g/cm3
Appearence

Flecainide appears as a white to off-white crystalline powder. It is typically odorless and is available in solid form when purified.

Comment on solubility

Solubility of 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium bromide

The solubility of the compound 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium bromide (C22H28F1N2O3) can be influenced by several factors including:

  • Polarity: This compound features both polar and non-polar functional groups. The methoxy groups contribute to its polar character which can enhance solubility in polar solvents such as water or alcohols.
  • Ionic Interaction: As a bromide salt, it is likely to exhibit improved solubility in water through ion-dipole interactions, particularly given the presence of the +N ion.
  • Temperature: Solubility often increases with temperature. Therefore, dissolving this compound in warmer solvents may yield better results.
  • Solvent Choice: Ideal solvents for dissolving this compound could include a mix of polar aprotic solvents. It may show limited solubility in non-polar solvents due to its overall structure.

Overall, while the specific quantitative solubility data for this compound might be limited, understanding its molecular structure gives insights into its potential solubility behavior. Remember, "the solubility spectrum isn't just a number; it's a story of molecular interactions and affinities." Therefore, experimenting with various solvent combinations will be key in determining its practical solubility.

Interesting facts

Interesting Facts about 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium; bromide

This compound is a fascinating example within the class of isoquinolines, which are known for their diverse biological activities. Here are some engaging insights into its structure and implications:

  • Biological Significance: Isoquinolines are recognized for their roles in medicinal chemistry. Many isoquinoline derivatives exhibit a range of pharmacological effects, including antitumor, neuroprotective, and antimicrobial properties.
  • Fluorine's Effect: The incorporation of a fluorophenyl group in this compound greatly modifies its electronic characteristics and lipophilicity, potentially enhancing the ability of the compound to cross biological membranes.
  • Mechanistic Insights: Research indicates that compounds like this one can influence neurotransmitter systems and may have implications for treating neurodegenerative diseases, highlighting the importance of learning more about their mechanisms.
  • Synthetic Interest: The synthesis of such compounds often involves complex multi-step reactions, making them a topic of interest in organic synthesis coursework and research.
  • Research Opportunities: Scientists are continually exploring novel derivatives to optimize efficacy and reduce side effects in therapeutic contexts, which makes this compound a potential candidate for further investigation.

In the words of a renowned chemist, “The beauty of chemical compounds lies not just in their structures, but in their potential to change lives.”
Understanding compounds like 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium; bromide is essential for pushing the boundaries of medicinal chemistry and unlocking new therapies.

Synonyms
Bromure de dimethoxy-6,7 dihydro-3,4 ortho-fluorobenzyl-1 isoquinoleinium [French]
ISOQUINOLINE, 3,4-DIHYDRO-6,7-DIMETHOXY-1-(o-FLUOROBENZYL)-, HYDROBROMIDE
6-7-Dimethoxy-1-(o-fluorobenzyl)-3,4-dihydroisoquinoline hydrobromide
10268-23-2
Bromure de dimethoxy-6,7 dihydro-3,4 ortho-fluorobenzyl-1 isoquinoleinium