1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

Identification

Molecular formula

C₁₈H₁₈FNO₂

CAS number

110925-12-1

IUPAC name

1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

State

At room temperature, this compound is a solid. It is typically handled and studied as a solid in laboratory settings, making it easy to manage within controlled environments.

Melting point (Celsius)

75.00

Melting point (Kelvin)

348.10

Boiling point (Celsius)

369.50

Boiling point (Kelvin)

642.70

General information

Molecular weight

271.31g/mol

Molar mass

271.3050g/mol

Density

1.1725g/cm³

Appearence

The compound appears as an off-white to pale yellow crystalline solid. It is typically synthesized in laboratories for research purposes, and its solid form presents a crystalline structure. This compound is sensitive to light and air, and should be stored in a tightly-closed container to prevent degradation.

Comment on solubility

Solubility of 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

The solubility of 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline is influenced by multiple factors, given its complex structure. While specific quantitative solubility data may be limited, the compound likely exhibits the following characteristics:

Polarity: The presence of multiple methoxy groups in the structure suggests potential polarity, which may enhance solubility in polar solvents.
Hydrophobic Interactions: The fluorophenyl and isoquinoline moieties contribute to the hydrophobic nature, possibly affecting solubility in non-polar solvents.
pH Dependence: As a nitrogen-containing base, solubility could vary significantly with pH changes, which might lead to protonation and altered solubility.
Solvent Compatibility: The compound is expected to be more soluble in organic solvents like ethanol or DMSO compared to water due to its hydrophobic regions.

In conclusion, while the specific solubility values of 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline in various solvents remain to be thoroughly explored, its solubility characteristics highlight the interplay of structural features. Understanding these interactions is crucial for applications in medicinal chemistry and pharmacology.

Interesting facts

Interesting Facts about 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

This intriguing compound, widely studied for its potential applications in medicinal chemistry, falls within the category of isoquinolines, which are known for their diverse biological properties. Here are some fascinating aspects of this compound:

Structural Diversity: The presence of both a fluorophenyl group and methoxy groups enhances the molecular complexity, which can influence its biological interactions and pharmacological properties.
Medical Relevance: Isoquinoline derivatives, including this compound, have shown promise in pharmacology, exhibiting potential effects such as:

Antitumor activity
Antimicrobial properties
Neuroprotective effects

Synthetic Pathways: The synthesis of such compounds often involves complex multi-step reactions, making it a fascinating subject for organic chemists. The challenge of developing efficient and environmentally friendly synthesis routes remains an area of active research.
Fluorination Impact: The incorporation of fluorine, as seen in this compound, is known to improve the pharmacokinetic properties of drugs. Fluorinated compounds often exhibit enhanced metabolic stability and increased bioavailability.
Chemical Libraries: Compounds like this contribute to chemical libraries used in drug discovery, facilitating screening processes to identify lead compounds for therapeutic development.

In summary, 1-[(2-fluorophenyl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline is not just another chemical entity; it is a potential gateway to innovative medical applications and a testament to the intricate relationships found in organic chemistry.