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Methadone Hydrochloride

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Identification
Molecular formula
C21H27NO2·HCl
CAS number
125-76-6
IUPAC name
1-[2-hydroxy-4-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one;methane;chloride
State
State

At room temperature, methadone hydrochloride is usually in a solid state.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
345.90g/mol
Molar mass
345.8980g/mol
Density
1.0030g/cm3
Appearence

Methadone hydrochloride typically appears as a white, crystalline powder.

Comment on solubility

Solubility of 1-[2-hydroxy-4-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one; methane; chloride

The solubility of the compound 1-[2-hydroxy-4-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one; methane; chloride can be analyzed through its structural and chemical characteristics. This compound is likely to exhibit varying levels of solubility depending on the solvent used due to its intricate molecular structure.

Factors Influencing Solubility

  • Polarity: The presence of polar functional groups, such as the hydroxyl group (-OH), generally increases solubility in polar solvents like water.
  • ionic character: The piperidinium group indicates a positively charged site, enhancing solubility in ionic solvents.
  • Hydrophobic regions: The butan-1-one segment has hydrophobic characteristics that can limit solubility in aqueous environments.

Due to these competing factors, this compound might demonstrate:

  1. Good solubility in polar organic solvents
  2. Moderate solubility in water, especially in ionized form
  3. Low solubility in non-polar solvents due to its hydrophobic regions

In summary, understanding the solubility behavior of this compound requires careful consideration of its functional groups and the solvent characteristics. As always, it is advisable to perform experimental evaluations to confirm solubility profiles in specific conditions.

Interesting facts

Interesting Facts About 1-[2-hydroxy-4-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one; methane; chloride

This intriguing compound is a part of the larger family of organic chemicals and has a range of interesting applications and properties. Here are some key points about this compound that highlight its significance in the field of chemistry:

  • Pharmacological Potential: The unique structure of this compound suggests potential use in pharmaceutical applications. Compounds with piperidine moieties often exhibit important biological activities, making this compound a candidate for further drug development research.
  • Structure-Activity Relationship: Understanding how modifications to the piperidine ring and the phenyl derivatives affect biological activity can provide valuable insights for medicinal chemistry. This compound serves as an interesting example of structure-activity relationships (SAR).
  • Ion Exchange Properties: The presence of a quaternary ammonium group (the piperidin-1-ium) indicates potential for ion-exchange characteristics. Such properties may be harnessed in various industrial applications including catalysis and separation technologies.
  • Applications in Research: Compounds that include both hydroxy groups and quaternized amines often play critical roles as intermediates in synthetic chemistry, particularly in the design of larger and more complex molecules.
  • Stability and Reactivity: Investigating the stability and reactivity of the butan-1-one structure in various chemical environments can provide insights into its possible applications and assist in predicting its behavior in biological systems.

In conclusion, 1-[2-hydroxy-4-(2-piperidin-1-ium-1-ylethoxy)phenyl]butan-1-one; methane; chloride not only showcases the complexity and beauty of organic molecules but also highlights the importance of interdisciplinary research in medicine and chemistry. As quoted by renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound certainly exemplifies the intersection of creativity and science.

Synonyms
Butyrophenone, 6'-hydroxy-4'-(2-piperidinoethoxy)-, hydrochloride
2'-Hydroxy-4'-(2-piperidinoethoxy)butyrophenone hydrochloride
BUTYROPHENONE, 2'-HYDROXY-4'-(2-PIPERIDINOETHOXY)-, HYDROCHLORIDE
20800-23-1
RefChem:331372