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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
1-(2-hydroxyethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one
State
State

Nitrofurantoin is typically a solid at room temperature.

Melting point (Celsius)
272.00
Melting point (Kelvin)
545.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
238.16g/mol
Molar mass
238.1560g/mol
Density
1.6800g/cm3
Appearence

Nitrofurantoin is a yellow or yellowish-orange crystalline powder. The compound is relatively odorless and has a bitter taste.

Comment on solubility

Solubility of 1-(2-hydroxyethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one

The solubility of complex organic compounds like 1-(2-hydroxyethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one can be influenced by various factors, leading to its unique behavior in solvents. Here are some essential aspects to consider:

  • Polarity: The presence of both hydroxyethyl and nitro groups in the molecular structure often suggests a level of polarity, which can enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxy group can form hydrogen bonds with water molecules, thereby potentially increasing solubility.
  • Solvent Interaction: It’s crucial to identify which solvents can effectively solvate this compound. For example, polar solvents typically offer better solubility than non-polar solvents.
  • Influence of pH: The solubility may vary with changes in pH, particularly if the compound can ionize under certain conditions, affecting its solubility profile.

In summary, the solubility of 1-(2-hydroxyethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one is likely to be influenced by its polar functional groups and the ability to engage in hydrogen bonding, making it important to consider the solvent environment carefully. Understanding how these interactions work helps predict the behavior of such compounds in various applications.

Interesting facts

Interesting Facts about 1-(2-hydroxyethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one

This compound is an intriguing member of the imidazolidinone family, characterized by its diverse applications in medicinal chemistry. Here are some fascinating points to consider:

  • Structure and Function: The imidazolidinone skeleton in this compound offers unique properties that can function as bioactive agents, essential in the development of pharmaceuticals.
  • Bioactivity: The presence of the 5-nitro-2-furyl group is significant, as nitrofurans are known for their antibacterial and antiprotozoal activities. This makes this compound a potential candidate for therapeutic applications.
  • Mechanism of Action: Compounds like this one often work by interfering with bacterial DNA and protein synthesis, which is crucial in combating resistant strains of pathogens.
  • Versatility: The hydroxyethyl group enhances the solubility and bioavailability of the compound, increasing its potential therapeutic efficacy.
  • Research Potential: With ongoing studies into the synthesis of derivatives, this compound may lead to the discovery of new drugs aimed at various infectious diseases.

In summary, 1-(2-hydroxyethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidin-2-one is more than just a chemical structure; it represents the ongoing quest in the realm of drug discovery and the fight against resistant infections.

As a quote often heard in the scientific community goes, "Chemistry is the art of conversion; it allows us to reshape the world one compound at a time." Each new compound like this one brings us a step closer to novel therapies and innovations.

Synonyms
1-(2-HYDROXYETHYL)-3-{[(5-NITROFURAN-2-YL)METHYLIDENE]AMINO}IMIDAZOLIDIN-2-ONE
DTXSID20859895
NS00125924